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Millipore/04-1061 | Anti-phospho-Neurofilament M (Ser614/Ser619) Antibody, clone EPR580(2)Y, rabbit monoclonal/04-1061/1
  • Millipore/04-1061 | Anti-phospho-Neurofilament M (Ser614/Ser619) Antibody, clone EPR580(2)Y, rabbit monoclonal/04-1061/1

Millipore/04-1061 | Anti-phospho-Neurofilament M (Ser614/Ser619) Antibody, clone EPR580(2)Y, rabbit monoclonal/04-1061/1

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貨號(hào): 04-1061
品牌: Millipore
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    • Description
      CatalogueNumber04-1061
      DescriptionAnti-phospho-NeurofilamentM(Ser614/Ser619)Antibody,cloneEPR580(2)Y,rabbitmonoclonal
      AlternateNames
      • 68kDaneurofilamentprotein
      • NeurofilamenttripletLprotein
      • lightmolecularweightneurofilamentprotein
      • neurofilamentprotein,lightchain
      • neurofilamentsubunitNF-L
      • neurofilament,lightpolypeptide
      • neurofilament,lightpolypeptide68kDa
      BackgroundInformationNeurofilamentsareatypeofintermediatefilamentthatserveasmajorelementsoftheCytoskeletonsupportingtheaxoncytoplasm.Theyarethemostabundantfibrillarcomponentsoftheaxon,beingonaverage3-10timesmorefrequentthanaxonalmicrotubules.Neurofilaments(10nmindia.)arebuiltfromthreeintertwinedprotofibrilswhicharethemselvescomposedoftwotetramericprotofilamentcomplexofmonomericproteins.Theneurofilamenttripletproteins(68/70,160,and200kDa)occurinboththecentralandperipheralnervoussystemandareusuallyneuronspecific.The68/70kDaNF-Lproteincanself-assembleintoafilamentousstructure,howeverthe160kDaNF-Mand200kDaNF-Hproteinsrequirethepresenceofthe68/70kDaNF-Lproteintoco-assemble.Neuromas,ganglioneuromas,gangliogliomas,ganglioneuroblastomasandneuroblastomasstainpositivelyforneurofilaments.Althoughtypicallyrestrictedtoneurons,neurofilamentshavebeendetectedinparagangliomasandadrenalandextra-adrenalpheochromocytomas.Carcinoids,neuroendocrinecarcinomasoftheskin,andoatcellcarcinomasofthelungalsoexpressneurofilaments.
      ProductInformation
      FormatUnpurified
      Control
      • UntreatedandtreatedSHSY5Ycelllysate.
      PresentationRabbitMonoclonalinbuffercontaining50mMTris-Glycine(pH7.4),0.15MNaClcontaining40%Glycerol,0.01%sodiumazideand0.05%BSA.
      StorageandShippingInformation
      StorageConditionsStablefor1yearat-20oCfromdateofreceipt.
      HandlingRecommendations:Uponfirstthaw,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.Note:VariABIlityinfreezertemperaturesbelow-20°Cmaycauseglycerolcontainingsolutionstobecomefrozenduringstorage.
      Applications
      ApplicationPleasenotethatthisproductwillnotbeavailableforsaleafterMarch15,2015.Pleaseselectoneoftheotherantibodiesagainstthistarget.
      KeyApplications
      • WesternBlotting
      • Immunohistochemistry(Paraffin)
      BIOLOGicalInformation
      ImmunogenPhospho-syntheticpeptidecorrespondingtoresiduessurroundingSerine614/619ofhumanNeurofilamentM.
      EpitopePhosphorylatedSer614/Ser619
      CloneEPR580(2)Y
      HostRabbit
      SpecificityThisantibodyrecognizesphosphorylatedSer614/619ofNeurofilamentM.
      IsotypeIgG
      SpeciesReactivity
      • Human
      AntibodyTypeMonoclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryNeurofilamentsaretypeIVintermediatefilamentheteropolymerscomposedoflight,medium,andheavychains.Neurofilamentscomprisetheaxoskeletonandfunctionallymaintainneuronalcaliber.Theymayalsoplayaroleinintracellulartransporttoaxonsanddendrites.Thisgeneencodesthemediumneurofilamentprotein.ThisproteiniscommonlyusedasabioMarkerofneuronaldamage.Alternativesplicingresultsinmultipletranscriptvariantsencodingdistinctisoforms.
      GeneSymbol
      • CMT1F
      • CMT2E
      • FLJ53642
      • NF-L
      • NF68
      • NFL
      • neurofilament-light
      Modifications
      • Phosphorylation
      PurificationMethodUnpurified
      UniProtNumber
      UniProtSummaryFUNCTION:Neurofilamentsusuallycontainthreeintermediatefilamentproteins:L,M,andHwhichareinvolvedinthemaintenanceofneuronalcaliber.
      SUBUNITSTRUCTURE:InteractswithRGNEFBysimilarity.
      DOMAIN:Theextramassandhighchargedensitythatdistinguishtheneurofilamentproteinsfromallotherintermediatefilamentproteinsareduetothetailpieceextensions.Thisregionmayformachargedscaffoldingstructuresuitableforinteractionwithotherneuronalcomponentsorions.
      PTM:O-glycosylatedBysimilarity.
      INVOLVEMENTINDISEASE:DefectsinNEFLarethecauseofCharcot-Marie-Toothdiseasetype1F(CMT1F)[MIM:607734].CMT1FisaformofCharcot-Marie-Toothdisease,themostcommoninheriteddisorderoftheperipheralnervoussystem.Charcot-Marie-Toothdiseaseisclassifiedintwomaingroupsonthebasisofelectrophysiologicpropertiesandhistopathology:primaryperipheraldemyelinatingneuropathyorCMT1,andprimaryperipheralaxonalneuropathyorCMT2.NeuropathiesoftheCMT1grouparecharacterizedbyseverelyreducednerveconductionvelocities(lessthan38m/sec),segmentaldemyelinationandremyelinationwithonionbulbformationsonnervebiopsy,slowlyprogressivedistalmuscleatrophyandweakness,absentdeeptendonreflexes,andhollowfeet.CMT1Fischaracterizedbyonsetininfancyorchildhood(range1to13years).DefectsinNEFLarethecauseofCharcot-Marie-Toothdiseasetype2E(CMT2E)[MIM:607684].CMT2EisanautosomaldominantformofCharcot-Marie-Toothdiseasetype2.NeuropathiesoftheCMT2grouparecharacterizedbysignsofaxonalregenerationintheabsenceofobviousmyelinalterations,normalorslightlyreducednerveconductionvelocities,andprogressivedistalmuscleweaknessandatrophy.
      MISCELLANEOUS:NF-Listhemostabundantofthethreeneurofilamentproteinsand,astheothernonepithelialintermediatefilamentproteins,itcanformhomopolymeric10-nmfilaments.
      SEQUENCESIMILARITIES:Belongstotheintermediatefilamentfamily.
      MolecularWeight~160kDa
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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