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Millipore/04-1091 | Anti-Sir2/SIRT1 Antibody, clone E104, rabbit monoclonal/04-1091/100 µL
  • Millipore/04-1091 | Anti-Sir2/SIRT1 Antibody, clone E104, rabbit monoclonal/04-1091/100 µL

Millipore/04-1091 | Anti-Sir2/SIRT1 Antibody, clone E104, rabbit monoclonal/04-1091/100 µL

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貨號: 04-1091
品牌: Millipore
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    • Description
      CatalogueNumber04-1091
      DescriptionAnti-Sir2/SIRT1Antibody,cloneE104,rabbitmonoclonal
      AlternateNames
      • SIR2-likeprotein2
      • silencinginformationregulator2-like
      • silentinformationregulator2
      • sir2-relatedproteintype2
      • sirtuin(silentmatingtypeinformationregulation2
      • homolog)2(S.cerevisiae)
      • sirtuin(silentmatingtypeinformationregulation2,
      • S.cerevisiae,homolog)2
      • sirtuin2
      • sirtuintype2
      BackgroundInformationSir2isshortforSilentmatingtypeInformationRegulation-2.Sir2(whosehomologinmammalsisknownasSIRT1,SIR2L1orSir2α)isthenamesakeofafamilyofcloselyrelatedenzymes,thesirtuins.Membersofthisfamilyhavebeenfoundinnearlyallorganismsstudied.Sirtuinsarehypothesizedtoplayakeyroleinanorganism"sresponsetostresses(suchasheatorstarvation)andtoberesponsIBLefortheLifespan-extendingeffectsofcalorierestriction.SirtuinsactbyremovingacetylgroupsfromproteinsinthepresenceofNAD+;theyarethusclassifiedas"NAD+-dependentdeacetylases".Inmammals,SIRT1(themammalianhomologofSir2)hasbeenshowntodeacetylateandtherebydeactivatethep53protein.
      ProductInformation
      FormatUnpurified
      Control
      • Jurkatcelllysate
      PresentationRabbitMonoclonalinbuffercontaining50mMTris-Glycine(pH7.4),0.15MNaClcontaining40%Glycerol,0.01%sodiumazideand0.05%BSA.
      StorageandShippingInformation
      StorageConditionsStablefor1yearat-20oCfromdateofreceipt.HandlingRecommendations:Uponfirstthaw,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.Note:VariABIlityinfreezertemperaturesbelow-20°Cmaycauseglycerolcontainingsolutionstobecomefrozenduringstorage.
      Applications
      ApplicationPleasenotethatthisproductwillnotbeavailableforsaleafterMarch15,2015.Pleaseselectoneoftheotherantibodiesagainstthistarget.
      KeyApplications
      • Immunoprecipitation
      • WesternBlotting
      • Immunocytochemistry
      • Immunohistochemistry(Paraffin)
      ApplicationNotesImmunohistochemistryAnalysis:A1:100-250dilutionfromapreviouslotdetectedSir2inhumancolonandlungsquamouscarcinomatissue.
      ImmunocytochemistryAnalysis:A1:100-250dilutionfromapreviouslotwasusedinIC.
      ImmunoprecipitationAnalysis:A1:50dilutionfromapreviouslotwasusedinIP.
      BIOLOGicalInformation
      ImmunogenSyntheticpeptidecorrespondingtoresiduesnearC-terminusandbeforeAla-richdomainofhumanSir2.
      EpitopeC-terminus
      CloneE104
      HostRabbit
      SpecificityTheantibodydoesnotcross-reactwithothersirtuinfamilymembers.
      IsotypeIgG
      SpeciesReactivity
      • Human
      AntibodyTypeMonoclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryThisgeneencodesamemberofthesirtuinfamilyofproteins,homologstotheyeastSir2protein.Membersofthesirtuinfamilyarecharacterizedbyasirtuincoredomainandgroupedintofourclasses.Thefunctionsofhumansirtuinshavenotyetbeendetermined;however,yeastsirtuinproteinsareknowntoregulateepigeneticgenesilencingandsuppressrecombinationofrDNA.Studiessuggestthatthehumansirtuinsmayfunctionasintracellularregulatoryproteinswithmono-ADP-ribosyltransferaseactivity.TheproteinencodedbythisgeneisincludedinclassIofthesirtuinfamily.Alternativesplicingresultsinmultipletranscriptvariants.
      GeneSymbol
      • EC3.5.1.-
      • SIR2
      • SIR2-like
      • SIR2L
      • SIR2L2
      PurificationMethodUnpurified
      UniProtNumber
      UniProtSummaryFUNCTION:NAD-dependentdeacetylase,whichdeacetylatesthe"Lys-40"ofalpha-tubulin.Involvedinthecontrolofmitoticexitinthecellcycle,probablyviaitsroleintheregulationofCytoskeleton.Despitesomeabilitytodeacetylatehistonesinvitro,itisunlikelyinvivo.
      CATALYTICACTIVITY:NAD++anacetylprotein=nicotinamide+O-acetyl-ADP-ribose+aprotein.
      COFACTOR:Binds1zincionpersubunit.
      ENZYMEREGULATION:InhibitedbySirtinol,A3andM15smallmolecules.Inhibitedbynicotinamide.
      SUBUNITSTRUCTURE:InteractswithHDAC6,suggestingthattheseproteinsbelongtoalargecomplexthatdeacetylatethecytoskeleton.
      SUBCELLULARLOCATION:Cytoplasm?cytoskeleton.Note:Colocalizeswithmicrotubules.
      TISSUESPECIFICITY:Widelyexpressed.Highlyexpressedinheart,brainandskeletalmuscle,whileitisweaklyexpressedinplacentaandlung.Down-regulatedinmanygliomassuggestingthatitmayactasatumorsuppressorgeneinhumangliomaspossiblythroughtheregulationofmicrotubulenetwork.
      DEVELOPMENTALSTAGE:Peaksduringmitosis.Aftermitosis,itisprobablydegradedbythe26Sproteasome.
      PTM:PhosphorylatedattheG2/Mtransitionofthecellcycle.
      SEQUENCESIMILARITIES:Belongstothesirtuinfamily.
      Contains1deacetylasesirtuin-typedomain.
      SEQUENCECAUTION:ThesequenceAAF67015.1differsfromthatshown.Reason:Frameshiftatseveralpositions.
      MolecularWeight~110kDa
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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