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Millipore/04-229 | Anti-HDAC2 Antibody, clone Y461, rabbit monoclonal/04-229/100 µL
  • Millipore/04-229 | Anti-HDAC2 Antibody, clone Y461, rabbit monoclonal/04-229/100 µL

Millipore/04-229 | Anti-HDAC2 Antibody, clone Y461, rabbit monoclonal/04-229/100 µL

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貨號: 04-229
品牌: Millipore
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    • Description
      CatalogueNumber04-229
      BrandFamilyUpstate
      TradeName
      • Upstate
      DescriptionAnti-HDAC2Antibody,cloneY461,rabbitmonoclonal
      AlternateNames
      • YY1-associatedfactor1
      • histonedeacetylase2
      • transcriptionalregulatorhomologRPD3
      BackgroundInformationHistonedeacetylase2(HDAC2),ortranscriptionalregulatorhomologRPD3L1,ishighlyhomologoustotheyeasttranscriptionfactorRPD3(reducedpotassiumdependency3)gene.Asinyeast,humanHDA2islikelytobeinvolvedinregulatingchromatinstructureduringtranscription.IthasbeenimplicatedtoassociatewithYY1,amammalianzinc-fingertranscriptionfactor,whichnegativelyregulatestranscriptionbytetheringRPD3toDNAasacofactor.Thisprocessishighlyconservedfromyeasttohuman.
      ProductInformation
      FormatCultureSupernatant
      Control
      • K562wholecelllysate.
      PresentationUnpurifiedrabbitmonoclonalIgGinbuffercontaining50mMTris-Glycine(pH7.4),0.15MNaCl,40%Glycerol,0.01%sodiumazideand0.05%BSA.
      StorageandShippingInformation
      StorageConditionsStablefor1yearat-20oCfromdateofreceipt.
      HandlingRecommendations:Uponfirstthaw,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.Note:VariABIlityinfreezertemperaturesbelow-20°Cmaycauseglycerolcontainingsolutionstobecomefrozenduringstorage.
      Applications
      ApplicationPleasenotethatthisproductwillnotbeavailableforsaleafterMarch15,2015.Pleaseselectoneoftheotherantibodiesagainstthistarget.
      KeyApplications
      • FlowCytometry
      • Immunocytochemistry
      • Immunohistochemistry
      • Immunohistochemistry(Paraffin)
      • Immunoprecipitation
      • WesternBlotting
      ApplicationNotesFlowCytometry:
      1:60dilutionofapreviouslotwasusedonflowcytometry.

      Immunoprecipitation:
      1:60dilutionofapreviouslotwasusedonimmunoprecipitation.

      Immunocytochemistry:
      1:250-500dilutionofapreviouslotwasusedinimmunocytochemistry.

      Immunohistochemistry:
      1:250-500dilutionofapreviouslotwasusedinimmunohistochemistry.



      BIOLOGicalInformation
      ImmunogenKLHconjugatedtoasyntheticpeptidefromtheC-terminalregionofhumanHistoneDeacetylase2.
      EpitopeC-terminus
      CloneY461
      HostRabbit
      SpecificityThisantibodyrecognizesHistoneDeacetylase2attheC-terminus.
      IsotypeIgG
      SpeciesReactivity
      • Human
      • Mouse
      • Rat
      SpeciesReactivityNoteDemonstratedtoreactwithhuman,mouseandratHDAC2.
      AntibodyTypeMonoclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryThisgeneproductbelongstothehistonedeacetylasefamily.HistonedeacetylasesactviatheformationoflargemultiproteincomplexesandareresponsIBLeforthedeacetylationoflysineresiduesontheN-terminalregionofthecorehistones(H2A,H2B,H3andH4).Thisproteinalsoformstranscriptionalrepressorcomplexesbyassociatingwithmanydifferentproteins,includingYY1,amammalianzinc-fingertranscriptionfactor.Thusitplaysanimportantroleintranscriptionalregulation,cellcycleprogressionanddevelopmentalevents.[providedbyRefSeq].
      GeneSymbol
      • EC3.5.1.98
      • HD2
      • OTTHUMP00000040427
      • RPD3
      • YAF1
      PurificationMethodUnpurified
      UniProtNumber
      UniProtSummaryFUNCTION:SwissProt:Q92769#FormstranscriptionalrepressorcomplexesbyassociatingwithMAD,SIN3,YY1andN-COR.InteractsinthelateS-phaseofDNA-replicationwithDNMT1intheothertranscriptionalrepressorcomplexcomposedofDNMT1,DMAP1,PCNA,CAF1.

      SIZE:488aminoacids;55364Da

      SUBUNIT:Interactswiththenon-histoneregionofH2AFY(Bysimilarity).Partofthecorehistonedeacetylase(HDAC)complexcomposedofHDAC1,HDAC2,RBBP4andRBBP7.ThecorecomplexassociateswithMTA2,MBD3,MTA1L1,CHD3andCHD4toformthenucleosomeremodelingandhistonedeacetylation(NuRD)complex,orwithSIN3,SAP18andSAP30toformtheSIN3HDACcomplex.ComponentofaBHChistonedeacetylasecomplexthatcontainsHDAC1,HDAC2,HMG20B/BRAF35,AOF2/LSD1,RCOR1/CoRESTandPHF21A/BHC80.TheBHCcomplexmayalsocontainZMYM2,ZNF217,ZMYM3,GSE1andGTF2I.PartofacomplexcontainingthecorehistonesH2A,H2B,H3andH4,DEKandunphosphorylatedDAXX.PartofacomplexcontainingATRandCHD4.FormsaheterologouscomplexatleastwithYY1.InteractswithATR,DNMT1,MINT,HDAC7,HDAC10,HCFC1,NRIP1,MJD2A/JHDM3A,SAP30,SETDB1andSUV39H1.Interactswiththenon-histoneregionofH2AFY.InteractswithPELP1.ComponentofamSin3AcorepressorcomplexthatcontainsSIN3A,SAP130,SUDS3/SAP45,ARID4B/SAP180,HDAC1andHDAC2.InteractswithCBFA2T3.InteractswithSAP30L.

      SUBCELLULARLOCATION:Nucleus.

      TISSUESPECIFICITY:Widelyexpressed;lowerlevelsinbrainandlung.

      SIMILARITY:SwissProt:Q92769##Belongstothehistonedeacetylasefamily.Type1subfamily.
      MolecularWeight55kDa
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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