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Millipore/04-797 | Anti-phospho-MAP Kinase 1/2 (Erk1/2)(Thr185/Tyr187) Antibody, clone AW39/04-797/100 µL
  • Millipore/04-797 | Anti-phospho-MAP Kinase 1/2 (Erk1/2)(Thr185/Tyr187) Antibody, clone AW39/04-797/100 µL

Millipore/04-797 | Anti-phospho-MAP Kinase 1/2 (Erk1/2)(Thr185/Tyr187) Antibody, clone AW39/04-797/100 µL

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貨號: 04-797
品牌: Millipore
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    • Description
      CatalogueNumber04-797
      Replaces05-797
      BrandFamilyUpstate
      TradeName
      • Upstate
      DescriptionAnti-phospho-MAPKinase1/2(Erk1/2)(Thr185/Tyr187)Antibody,cloneAW39
      AlternateNames
      • Mitogen-activatedproteinkinase
      • Extracellularsignal-regulatedkinase
      • proteintyrosinekinaseERK2
      BackgroundInformationErk(Extracellularsignal-RelatedKinase)isafamilyoftwo,highlyhomologousproteinsdenotedasErk1(p44,MAPK3)andErk2(p42,MAPK1)thatbothfunctioninthesamepathway.ThetwoproteinsareoftenreferredtocollectivelyasERK1/2orp44/p42MAPkinase.TheErkpathwayisconsideredtheclassical,canonicalMAPK(Mitogen-ActivatedProteinKinase)signalingpathway.Itisanevolutionarilyconservedpathwaythatcontrolsandisacriticalregulatorthegrowthandsurvivalthroughthepromotionofcellproliferationandthepreventionofapoptosis.Erkisinvolvedinthecontrolofmanyfundamentalcellularprocessesincludingcellproliferation,survival,differentiation,apoptosis,motilityandmetabolism.Erkisactivatedbygrowthfactorstimulationofreceptortyrosinekinases(RTKs)and/orintegrinstimulation.ThisactivatestheRas-Raf-MEK,-ErkpathwaythatresultsinMEK,adualkinase(aSer/ThrandaTyrkinase),phosphorylationandactivationofERK1/2(p44/044)ontheTxYmotif(Thr202/Tyr204andThr185/Tyr187forErk1andErk2,respectively).
      ProductInformation
      FormatPurified
      Control
      • RIPAcelllysatefromNGFstimulatedPC-12cells
      PresentationCulturedsupernantantin0.05%sodiumazide
      StorageandShippingInformation
      StorageConditionsMaintainfor2yearsat-20°Cfromdateofshipment.Aliquottoavoidrepeatedfreezingandthawing.Formaximumrecoveryofproduct,centrifugetheoriginalvialafterthawingandpriortoremovingthecap.
      Applications
      KeyApplications
      • Multiplexing
      • WesternBlotting
      ApplicationNotesWesternBlotAnalysis:
      A1:2,000-1:8,000dilutionofthislotdetectedphospho-MAPKinase1/2(Erk1/2)inRIPAlysatesfromNGFstimulatedPC-12cells(FigureA).
      Beadlyte?Phospho-SpecificityAssay:
      1:500-1:4,000dilutionsofapreviouslotdetectedactivebutnotunactiveMAPKinase/Erk2conjugatedtoLuminex?microspheres.(FigureB).
      BIOLOGicalInformation
      ImmunogenKLH-conjugated,syntheticpeptidecorrespondingtoaminoacidssurroundingthepTEpYmotifofhumanphospho-MAPKinase1/2(Erk1/2),inwhichtheThrandTyrresiduesarephosphorylated.Theimmunizingsequenceishighlyconservedamongspecies.
      CloneAw39
      ConcentrationVariable
      HostRabbit
      SpecificityRecognizesphosphorylatedMAPKinase1and2(Erk1&2).
      IsotypeIgG
      SpeciesReactivity
      • Human
      • Rat
      SpeciesReactivityNoteHumanandrat.Predictedtocross-reactwithmanyspeciesbasedonsequencehomology.
      AntibodyTypeMonoclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryTheproteinencodedbythisgeneisamemberoftheMAPkinasefamily.MAPkinases,alsoknownasextracellularsignal-regulatedkinases(ERKs),actasanintegrationpointformultiplebiochemicalsignals,andareinvolvedinawidevarietyofcellularprocessessuchasproliferation,differentiation,transcriptionregulationanddevelopment.Theactivationofthiskinaserequiresitsphosphorylationbyupstreamkinases.Uponactivation,thiskinasetranslocatestothenucleusofthestimulatedcells,whereitphosphorylatesnucleartargets.Twoalternativelysplicedtranscriptvariantsencodingthesameprotein,butdifferingintheUTRs,havebeenreportedforthisgene.
      GeneSymbol
      • MAPK1
      • p38
      • ERK
      • P42MAPK
      • ERK2
      • p40
      • PRKM1
      • p41mapk
      • PRKM2
      • MAPK2
      • p42-MAPK
      • p41
      • ERK-2
      • ERT1
      Modifications
      • Phosphorylation
      UniProtNumber
      UniProtSummaryFUNCTION:SwissProt:P28482#Involvedinboththeinitiationandregulationofmeiosis,mitosis,andpostmitoticfunctionsindifferentiatedcellsbyphosphorylatinganumberoftranscriptionfactorssuchasELK1.PhosphorylatesEIF4EBP1;requiredforinitiationoftranslation.Phosphorylatesmicrotubule-associatedprotein2(MAP2).PhosphorylatesSPZ1(Bysimilarity).Phosphorylatesheatshockfactorprotein4(HSF4).
      COFACTOR:Magnesium(Bysimilarity).
      SIZE:360aminoacids;41390Da
      SUBUNIT:InteractswithMORG1(Bysimilarity).BindstoHIV-1NefthroughitsSH3domain.Thisinteractioninhibitsitstyrosine-kinaseactivity.InteractswithHSF4.
      DOMAIN:SwissProt:P28482TheTXYmotifcontainsthethreonineandtyrosineresidueswhosephosphorylationactivatestheMAPkinases.
      PTM:DuallyphosphorylatedonThr-185andTyr-187,whichactivatestheenzyme.
      SIMILARITY:Belongstotheproteinkinasesuperfamily.CMGCSer/Thrproteinkinasefamily.MAPkinasesubfamily.&Contains1proteinkinasedomain.
      MolecularWeightMAPK1(~44kDa)andMAPK2(~42kDa).
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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