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Millipore/04-858 | Anti-Histone H4 Antibody, pan, rabbit monoclonal/04-858/100 µL
  • Millipore/04-858 | Anti-Histone H4 Antibody, pan, rabbit monoclonal/04-858/100 µL

Millipore/04-858 | Anti-Histone H4 Antibody, pan, rabbit monoclonal/04-858/100 µL

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貨號: 04-858
品牌: Millipore
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    • Description
      CatalogueNumber04-858
      Replaces05-858
      BrandFamilyUpstate
      TradeName
      • Upstate
      DescriptionAnti-HistoneH4Antibody,pan,rabbitmonoclonal
      OverviewThisantibodyrecognizeshistoneH4independantofanypost-translationalmodifications.
      AlternateNames
      • H4
      • HistoneH4
      BackgroundInformationHistonesarehighlyconservedproteinsthatserveasthestructuralscaffoldfortheorganizationofnuclearDNAintochromatin.Thehistoneshaveanaminoterminaltail,aglobulardomain,andacarboxy-terminaltail.Thefourcorehistones,H2A,H2B,H3andH4assembleintotheoctamer(2moleculesofeach).Subsequently,146basepairsofDNAarewrappedinasequence-independentmanneraroundtheoctamer,formingthebasicsubunitofchromatin,thenucleosome.HistoneH4isoneofthe5mainhistoneproteinsinvolvedinthestructureofchromatinineukaryoticcells.FeaturingamainglobulardomainandalongNterminaltail,H4isinvolvedwiththestructureofthenucleosomesofthe"beadsonastring"structure.
      ProductInformation
      FormatCultureSupernatant
      Control
      • RecombinantHistoneH4(Catalog#14-412)orHeLacellacidextract.
      PresentationCulturedsupernantantin0.05%sodiumazide.
      StorageandShippingInformation
      StorageConditionsStablefor1yearat-20°Cfromdateofreceipt.
      Formaximumrecoveryofproduct,centrifugethevialpriortoremovingthecap.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.
      Applications
      ApplicationAnti-HistoneH4Antibody,panisaRabbitMonoclonalAntibodyfordetectionofHistoneH4alsoknownasHistoneH4&hasbeenvalidatedinChIP,WB,Mplex.
      KeyApplications
      • WesternBlotting
      • Multiplexing
      • ChromatinImmunoprecipitation(ChIP)
      ApplicationNotesImmunoblotAnalysis:
      A1:100,000dilutionofapreviouslotdetectedunmodifiedrecombinantHistoneH4protein(Catalog#14-412)andHistoneH4inacidextractsfrombothuntreatedHeLacellsandcellstreatedwithsodiumbutyrate(hyper-acetylated)orcolcemid(hyper-phosphorylated)(FigureB).

      ChromatinImmunoprecipitation:
      Anindependentlaboratoryusedapreviouslotofthisantibodyinchromatinimmunoprecipitation(Issac,C.,2006).

      Multiplexing:
      SerialdilutionsofapreviouslotwereincubatedwithhistonepeptidescontainingvariousunmodifiedpeptidesspanningtheaminoterminusofHistoneH4conjugatedtoLuminex?microspheres.Theantibodyrecognizedbothmodifiedandunmodifiedpeptides.
      BIOLOGicalInformation
      ImmunogenSyntheticpeptidecorrespondingtoaminoacids17-28ofHistoneH4.Epitopehasbeenmappedtoresidues25-28
      Epitopea.a.25-28
      Clone62-141-13
      HostRabbit
      SpecificityRecognizesHistoneH4.
      IsotypeIgG
      SpeciesReactivity
      • Chicken
      • Human
      • Vertebrates
      • Yeast(S.cerevisiae)
      AntibodyTypeMonoclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryHistonesarebasicnuclearproteinsthatareresponsIBLeforthenucleosomestructureofthechromosomalfiberineukaryotes.Twomoleculesofeachofthefourcorehistones(H2A,H2B,H3,andH4)formanoctamer,aroundwhichapproximately146bpofDNAiswrappedinrepeatingunits,callednucleosomes.Thelinkerhistone,H1,interactswithlinkerDNAbetweennucleosomesandfunctionsinthecompactionofchromatinintohigherorderstructures.ThisgeneisintronlessandencodesamemberofthehistoneH4family.TranscriptsfromthisgenelackpolyAtailsbutinsteadcontainapalindromicterminationelement.Thisgeneisfoundinthelargehistonegeneclusteronchromosome6.
      GeneSymbol
      • HIST1H4A
      • H4/J
      • HIST1H4F
      • HIST1H4L
      • H4FN
      • H4FA
      • H4FH
      • HIST1H4H
      • H4F2
      • H4FM
      • H4/A
      • H4FK
      • H4FG
      • HIST2H4
      • H4FB
      • H4/K
      • HIST1H4I
      • H4/N
      • HIST1H4B
      • H4FE
      • H4/M
      • H4/a
      • HIST1H4E
      • HIST4H4
      • HIST2H4A
      • H4FC
      • H4FI
      • H4/H
      • HIST1H4C
      • H4/G
      • HIST1H4K
      • H4FJ
      • H4FD
      • H4/I
      • H4/B
      • H4/D
      • H4/C
      • HIST1H4J
      • HIST1H4D
      • H4/E
      UniProtNumber
      UniProtSummaryFUNCTION:SwissProt:P62805#Corecomponentofnucleosome.NucleosomeswrapandcompactDNAintochromatin,limitingDNAaccessibilitytothecellularmachinerieswhichrequireDNAasatemplate.Histonestherebyplayacentralroleintranscriptionregulation,DNArepair,DNAreplicationandchromosomalstABIlity.DNAaccessibilityisregulatedviaacomplexsetofpost-translationalmodificationsofhistones,alsocalledhistonecode,andnucleosomeremodeling.
      SIZE:103aminoacids;11367Da
      SUBUNIT:ThenucleosomeisahistoneoctamercontainingtwomoleculeseachofH2A,H2B,H3andH4assembledinoneH3-H4heterotetramerandtwoH2A-H2Bheterodimers.Theoctamerwrapsapproximately147bpofDNA.
      SUBCELLULARLOCATION:Nucleus.
      PTM:SymmetricdimethylationonArg-4bythePRDM1/PRMT5complexmayplayacrucialroleinthegerm-celllineage(Bysimilarity).&UbiquitinatedbytheCUL4-DDB-RBX1complexinresponsetoultravioletirrADIation.ThismayweakentheinteractionbetweenhistonesandDNAandfacilitateDNAaccessibilitytorepairproteins.
      SIMILARITY:SwissProt:P62805##BelongstothehistoneH4family.
      MolecularWeight10kDa
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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