Immunogen | N-terminal6His-taggedrecombinantfulllengthhumanGSK3β. |
Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
Host | Rabbit |
Specificity | GSK3alphaandbeta. |
Isotype | IgG |
SpeciesReactivity | |
SpeciesReactivityNote | Humanandmouse. Predictedtocross-reactwithratbasedonsequencehomology. |
AntibodyType | MonoclonalAntibody |
EntrezGeneNumber | |
EntrezGeneSummary | Glycogensynthasekinase3-alpha(GSK3A;EC{2.7.1.37})isamultifunctionalproteinserinekinase, homologoustoDrosophila"shaggy"(zeste-white3)andimplicatedinthecontrolof severalregulatoryproteinsincludingglycogensynthase(seeGYS1,{138570})andtranscription factors(e.g.,JUN,{165160}).ItalsoplaysaroleintheWNT({164820})andPI3K(seePIK3CG,{601232})signalingpathways(seereviewby{1:Alietal.(2001) |
GeneSymbol | |
UniProtNumber | |
UniProtSummary | FUNCTION:Implicatedinthehormonalcontrolofseveralregulatoryproteinsincludingglycogensynthase,MYBandthetranscriptionfactorJUNBysimilarity. CATALYTICACTIVITY:ATP+[tauprotein]=ADP+[tauprotein]phosphate. SUBUNITSTRUCTURE:MonomerBysimilarity. SEQUENCESIMILARITIES:Belongstotheproteinkinasesuperfamily.CMGCSer/Thrproteinkinasefamily.GSK-3subfamily. Contains1proteinkinasedomain.
|
MolecularWeight | ~46kDa(beta)and51kDa(alpha) |