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Millipore/05-1243 | Anti-Sirt1 Antibody, clone 3H10.2/05-1243/100 µg
  • Millipore/05-1243 | Anti-Sirt1 Antibody, clone 3H10.2/05-1243/100 µg

Millipore/05-1243 | Anti-Sirt1 Antibody, clone 3H10.2/05-1243/100 µg

價格: ￥5052.00 市場價: 8420.00
貨號: 05-1243
品牌: Millipore
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    • Description
      CatalogueNumber05-1243
      Replaces05-707
      BrandFamilyUpstate
      TradeName
      • Upstate
      DescriptionAnti-Sirt1Antibody,clone3H10.2
      BackgroundInformationTheSir2proteininyeastisknowntofunctionintranscriptionalsilencingprocessesthroughthedeacetylationofhistonesH3andH4.ThemorerecentlydescribedhumanhomologueofSir2,knownasSIRT1,hasbeenfoundtoassociatewiththetumorsuppressorproteinp53.TherearenowfivedescribedhumanhomologsofyeastSir2,whicharenamedSIRT1-5.
      SIRT1bindsanddeacetylatesp53withspecificityforitsC-terminalLys382residueinresponsetotheupregulationofpromyelocyticleukemiaprotein(PML)nuclearbodiesoroncogenicRas.Thedeacetylationofp53SIRT1hasbeenshowntonegativelyregulatep53-mediatedtranscription,preventingcellularsenescenceandapoptosisinducedbyDNAdamageandstress.SIRT1isaHDACwhichisimportantinestablishingrepressivechromatinstructuresandplaysaroleinincreasingLifespan.
      ProductInformation
      FormatPurified
      PresentationPurifiedinPBSwith0.05%SodiumAzide
      StorageandShippingInformation
      StorageConditionsMaintainat2-8°Cinundilutedaliquotsforupto6monthsafterdateofreceipt.Aliquottoavoidrepeatedfreezingandthawing.Formaximumrecoveryofproduct,centrifugetheoriginalvialafterthawingandpriortoremovingthecap.
      Applications
      ApplicationAnti-Sirt1Antibody,clone3H10.2isaMouseMonoclonalAntibodyfordetectionofSirt1alsoknownasSirtuin1,SilentmatingtypeInformationRegulation-2&hasbeentestedinIP&WB.
      KeyApplications
      • Immunoprecipitation
      • WesternBlotting
      BIOLOGicalInformation
      ImmunogenGSTfusionproteincorrespondingtoaminoacids508-616ofhumanSirt1.
      Clone3H10.2
      ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
      HostMouse
      SpecificityHumanSirt1.DoesnotcrossreactwithlysatesfrommouseNIH/3T3cellsorratPC12cells.
      IsotypeIgG1
      SpeciesReactivity
      • Human
      AntibodyTypeMonoclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryThisgeneencodesamemberofthesirtuinfamilyofproteins,homologstotheyeastSir2protein.Membersofthesirtuinfamilyarecharacterizedbyasirtuincoredomainandgroupedintofourclasses.Thefunctionsofhumansirtuinshavenotyetbeendetermined;however,yeastsirtuinproteinsareknowntoregulateepigeneticgenesilencingandsuppressrecombinationofrDNA.Studiessuggestthatthehumansirtuinsmayfunctionasintracellularregulatoryproteinswithmono-ADP-ribosyltransferaseactivity.TheproteinencodedbythisgeneisincludedinclassIofthesirtuinfamily.
      GeneSymbol
      • SIRT1
      • SIR2L1
      • hSIR2
      • OTTHUMP00000060745
      • hSIRT1
      • SIR2alpha
      PurificationMethodProteinGPurified
      UniProtNumber
      UniProtSummaryFUNCTION:SwissProt:Q96EB6#NAD-dependentdeacetylase,whichregulatesprocessessuchasapoptosisandmuscledifferentiationbydeacetylatingkeyproteins.Deacetylates"Lys-382"ofp53/TP53andimpairsitsABIlitytoinduceproapoptoticprogramandmodulatecellsenescence.DeacetylatesTAF1BandtherebyrepressesrDNAtranscriptionbytheRNApolymeraseI.InvolvedinHES1-andHEY2-mediatedtranscriptionalrepression.InhibitsskeletalmuscledifferentiationbydeacetylatingPCAFandMYOD1.MayserveasasensorofthecytosolicratioofNAD(+)/NADH,whichisessentialinskeletalmusclecelldifferentiation.Despitesomeabilitytodeacetylatehistonesinvitro,suchactivityiseitherweakorinexistentinvivo.IncaseofHIV-1infection,interactswithanddeacetylatestheviralTatprotein.
      COFACTOR:Binds1zincionpersubunit(Bysimilarity).
      SIZE:747aminoacids;81681Da
      SUBUNIT:InteractswithTAF1B.FoundinacomplexwithPCAFandMYOD1(Bysimilarity).InteractswithMLLT7/FOXO4,HES1,HEY2,p53/TP53andPML.
      SUBCELLULARLOCATION:Nucleus.Note=RecruitedtothenuclearbodiesviaitsinteractionwithPML.TISSUESPECIFICITY:Widelyexpressed.
      SIMILARITY:SwissProt:Q96EB6##Belongstothesirtuinfamily.&Contains1deacetylasesirtuin-typedomain.
      MISCELLANEOUS:Redwine,whichcontainsresveratrol,mayparticipateinactivationofsirtuinproteins,andmaythereforeparticipateinanextendedlifespanasithasbeenobservedinyeast.
      MolecularWeight120kDa
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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