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Millipore/05-429 | Anti-phospho-MBP Antibody, clone P12/05-429/100 µg
  • Millipore/05-429 | Anti-phospho-MBP Antibody, clone P12/05-429/100 µg

Millipore/05-429 | Anti-phospho-MBP Antibody, clone P12/05-429/100 µg

價格: ￥4068.00 市場價: 6780.00
貨號: 05-429
品牌: Millipore
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    • Description
      CatalogueNumber05-429
      BrandFamilyUpstate
      TradeName
      • Upstate
      DescriptionAnti-phospho-MBPAntibody,cloneP12
      BackgroundInformationMyelinbasicprotein(MBP)isthemajorextrinsicmembraneproteinofcentralnervoussystemandhasamolecularmassof21.5kDa.MBPisbelievedtobeimportantintheprocessofmyelinationofnervesinthecentralnervoussystem(CNS).MBPwasinitiallysequencedin1979afterisolationfrommyelinmembranes.Sincethattime,knockoutmicedeficientinMBPhavebeendevelopedwhichshoweddecreasedamountsofCNSmyelinationandaprogressivedisordercharacterizedbytremors,seizures,andearlydeath.ThegeneforMBPisonchromosome18;theproteinlocalizestotheCNSandtovariouscellsofthehematopoieticsystem.
      ThepoolofMBPinthecentralnervoussystemisverydiverse,withseveralsplicevariantsbeingexpressedandalargenumberofpost-translationalmodificationsontheprotein,whichincludephosphorylation,methylation,deamidationandcitrullination.MBPphosphorylationatThreonine125isacomplexregulatoryprocessthatmodulatesthecontributionofMBPtothestABIlityoftheMyelinsheath.
      InterestinMBPhascenteredonitsroleindemyelinatingdiseases,particularlymultiplesclerosis(MS).SeveralstudieshaveshownaroleforantibodiesagainstMBPinthepathogenesisofMS.SomestudieshavelinkedageneticpredispositiontoMStotheMBPgene,thoughamajorityhavenot.
      ProductInformation
      FormatPurified
      Control
      • Mousebrainextractorratbrainextract
      PresentationProteinGPurifiedimmunoglobulininProteinAPurifiedimmunoglobulinin30%glycerol,0.07MTris-glycine,pH7.4,0.105MNaCl,0.035%sodiumazideasapreservative.
      StorageandShippingInformation
      StorageConditionsMaintainfor2yearsat-20°Cfromdateofshipment.Aliquottoavoidrepeatedfreezingandthawing.Formaximumrecoveryofproduct,centrifugetheoriginalvialafterthawingandpriortoremovingthecap.
      Applications
      ApplicationDetectphospho-MBPusingthisAnti-phospho-MBPAntibody,cloneP12validatedforuseinEA&WB.
      KeyApplications
      • EnzymeAssays
      • WesternBlotting
      BIOLOGicalInformation
      ImmunogenSyntheticpeptidecorrespondingtothehumanmyelinbasicproteinsequencephosphorylatedatThr98andcoupledtotuberculin
      CloneP12
      HostMouse
      SpecificityRecognizesMBPphosphorylatedatThreonine98;SomepreparationsofMBPcontainbasallevelsofphosphorylatedMBP,whicharedetectedbythepMBPantibody.
      IsotypeIgG
      SpeciesReactivity
      • Vertebrates
      AntibodyTypeMonoclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryTheproteinencodedbytheclassicMBPgeneisamajorconstituentofthemyelinsheathofoligodendrocytesandSchwanncellsinthenervoussystem.However,MBP-relatedtranscriptsarealsopresentinthebonemarrowandtheimmunesystem.ThesemRNAsarisefromthelongMBPgene(otherwisecalled"Golli-MBP")thatcontains3additionalexonslocatedupstreamoftheclassicMBPexons.AlternativesplicingfromtheGolliandtheMBPtranscriptionstartsitesgivesriseto2setsofMBP-relatedtranscriptsandgeneproducts.TheGollimRNAscontain3exonsuniquetoGolli-MBP,splicedin-frameto1ormoreMBPexons.TheyencodehybridproteinsthathaveN-terminalGolliaasequencelinkedtoMBPaasequence.ThesecondfamilyoftranscriptscontainonlyMBPexonsandproducethewellcharacterizedmyelinbasicproteins.ThiscomplexgenestructureisconservedamongspeciessuggestingthattheMBPtranscriptionunitisanintegralpartoftheGollitranscriptionunitandthatthisarrangementisimportantforthefunctionand/orregulationofthesegenes.
      GeneSymbol
      • MBP
      • MGC99675
      Modifications
      • Phosphorylation
      PurificationMethodProteinAPurfied
      UniProtNumber
      UniProtSummaryFUNCTION:SwissProt:P02686#TheclassicgroupofMBPisoforms(isoform4-isoform14)arewithPLPthemostabundantproteincomponentsofthemyelinmembraneintheCNS.Theyhavearoleinbothitsformationandstabilization.Thesmallerisoformsmighthaveanimportantroleinremyelinationofdenudedaxonsinmultiplesclerosis.Thenon-classicgroupofMBPisoforms(isoform1-isoform3/Golli-MBPs)maypreferentiallyhavearoleintheearlydevelopingbrainlongbeforemyelination,maybeascomponentsoftranscriptionalcomplexes,andmayalsobeinvolvedinsignalingpathwaysinT-cellsandneuralcells.Differentialsplicingeventscombinedtooptionalpost-translationalmodificationsgiveawidespectrumofisomers,eachofthemhavingmaybeaspecializedfunction.InducesT-cellproliferation.
      SIZE:304aminoacids;33117Da
      SUBUNIT:Homodimer;isoform3existsasahomodimer.
      SUBCELLULARLOCATION:Myelinmembrane;Peripheralmembraneprotein;Cytoplasmicside.Note=Cytoplasmicsideofmyelin.
      TISSUESPECIFICITY:MBPisoformsarefoundinboththecentralandtheperipheralnervoussystem,whereasGolli-MBPisoformsareexpressedinfetalthymus,spleenandspinalcord,aswellasincelllinesderivedfromtheimmunesystem.DEVELOPMENTALSTAGE:Expressionturnsonabruptlyinfetusof14to16weeks.Evensmallerisoformsseemtobeproducedduringembryogenesis,someofthesepersistingintheadult.ExpressionofisoformMBP2ismoreevidentat16weeksanditsrelativeproportiondeclinedthereafter.
      PTM:SeveralchargeisomersofMBP;C1(themostcationic,leastmodified,andmostabundantform),C2,C3,C4,C5,C6,C7,C8-AandC8-B(theleastcationicform);areproducedasaresultofoptionalPTM,suchasphosphorylation,deamidationofglutamineorasparagine,argininecitrullinationandmethylation.C8-AandC8-BcontaineachtwomassisoformstermedC8-A(H),C8-A(L),C8-B(H)andC8-B(L),(H)standingforhigherand(L)forlowermolecularweight.C3,C4andC5arephosphorylated.Theratioofmethylatedarginineresiduesdecreasesinaging,makingtheproteinmorecationic.&TheN-terminalalanineisacetylated(isoform3,isoform4,isoform5andisoform6).&Arg-241wasfoundtobe6%monomethylatedand60%symmetricallydimethylated.
      DISEASE:SwissProt:P02686#Thereductioninthesurfacechargeofcitrullinatedand/ormethylatedMBPcouldresultinaweakenedattachmenttothemyelinmembrane.Thismechanismcouldbeoperativeindemyelinatingdiseasessuchaschronicalmultiplesclerosis(MS),andfulminatingMS(Marburgdisease).
      SIMILARITY:SwissProt:P02686##Belongstothemyelinbasicproteinfamily.
      MolecularWeight33kDa
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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