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Millipore/05-718 | Anti-PML Antibody, clone 36.1-104/05-718/200 µg
  • Millipore/05-718 | Anti-PML Antibody, clone 36.1-104/05-718/200 µg

Millipore/05-718 | Anti-PML Antibody, clone 36.1-104/05-718/200 µg

價格: ¥3696.00 市場價: 6160.00

貨號: 05-718
品牌: Millipore
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    • Description
      CatalogueNumber05-718
      BrandFamilyUpstate
      TradeName
      • Upstate
      DescriptionAnti-PMLAntibody,clone36.1-104
      BackgroundInformationPromyelocticLeukemiaGeneproduct(PML)isanuclearproteinwithgrowth-suppressivepropertiesoriginallyidentifiedinthecontextofthePML-retinoicreceptoralpha(RARalpha)fusionproteinofacutepromyelocyticleukemia.PMLlocalizeswithindistinctnuclearstructures,callednuclearbodies,whicharedisruptedbytheexpressionofPML-RARalpha.
      ProductInformation
      FormatPurified
      Control
      • MEF1celllysate
      PresentationProteinGPurifiedimmunoglobulinin0.1MTris-glycine,pH7.4,0.15MNaClwith0.05%sodiumazideasapreservative.
      StorageandShippingInformation
      StorageConditionsMaintainfor2yearsat-20°Cfromdateofshipment.Aliquottoavoidrepeatedfreezingandthawing.Formaximumrecoveryofproduct,centrifugetheoriginalvialafterthawingandpriortoremovingthecap.
      Applications
      ApplicationDetectPMLalsoknownasPromyelocyticLeukemiaProteinwithAnti-PMLAntibody,clone36.1-104(MouseMonoclonalAntibody),thathasbeendemonstratedtoworkinICC&WB.
      KeyApplications
      • Immunocytochemistry
      • WesternBlotting
      BIOLOGicalInformation
      Immunogen6HisfusionproteincorrespondingtomousePML(promyelocyticleukemiaprotein)
      Clone36.1-104
      ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
      HostMouse
      SpecificityRecognizesPML.
      IsotypeIgG
      SpeciesReactivity
      • Mouse
      AntibodyTypeMonoclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryTheproteinencodedbythisgeneisamemberofthetripartitemotif(TRIM)family.TheTRIMmotifincludesthreezinc-bindingdomains,aRING,aB-boxtype1andaB-boxtype2,andacoiled-coilregion.Thisphosphoproteinlocalizestonuclearbodieswhereitfunctionsasatranscriptionfactorandtumorsuppressor.Itsexpressioniscell-cyclerelatedanditregulatesthep53responsetooncogenicsignals.Thegeneisofteninvolvedinthetranslocationwiththeretinoicacidreceptoralphageneassociatedwithacutepromyelocyticleukemia(APL).Extensivealternativesplicingofthisgeneresultsinseveralvariationsoftheprotein"scentralandC-terminalregions;allvariantsencodethesameN-terminus.Alternativelysplicedtranscriptvariantsencodingdifferentisoformshavebeenidentified.
      GeneSymbol
      • PML
      • PP8675
      • RNF71
      • TRIM19
      • MYL
      PurificationMethodProteinGPurified
      UniProtNumber
      UniProtSummaryFUNCTION:SwissProt:P29590#Probabletranscriptionfactor.MayplayanimportantroleinrecruitmentofELF4intoPMLnuclearbodies.
      SIZE:882aminoacids;97517Da
      SUBUNIT:InteractswithSIRT1,TOPBP1,TRIM27andTRIM69.InteractswiththeC-terminusofELF4.InteractswithLassavirusZproteinandrABIesvirusphosphoprotein(Bysimilarity).
      SUBCELLULARLOCATION:Nucleus.Note=LocalizedtoPMLnuclearbodies.
      PTM:Ubiquitinated;mediatedbySIAH1orSIAH2andleADIngtoitssubsequentproteasomaldegradation.
      DISEASE:SwissProt:P29590#AchromosomalaberrationinvolvingPMLmaybeacauseofacutepromyelocyticleukemia(APL).Translocationt(15;17)(q21;q21)withRARA.ThePMLbreakpoints(typeAandtypeB)lieoneithersideofanalternativelysplicedexon.
      SIMILARITY:SwissProt:P29590##Contains2Bbox-typezincfingers.&Contains1RING-typezincfinger.
      MolecularWeight90-106kDa
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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