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Millipore/06-519 | Anti-phospho-CREB (Ser133) Antibody/06-519/100 µL
  • Millipore/06-519 | Anti-phospho-CREB (Ser133) Antibody/06-519/100 µL

Millipore/06-519 | Anti-phospho-CREB (Ser133) Antibody/06-519/100 µL

價(jià)格: ￥3816.00 市場(chǎng)價(jià): 6360.00
貨號(hào): 06-519
品牌: Millipore
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    • Description
      CatalogueNumber06-519
      BrandFamilyUpstate
      TradeName
      • Upstate
      DescriptionAnti-phospho-CREB(Ser133)Antibody
      AlternateNames
      • activetranscriptionfactorCREB
      • cAMPresponsiveelementbindingprotein1
      • cAMP-responseelement-bindingprotein-1
      • transactivatorprotein
      BackgroundInformationCREBisaβ-ZIPtranscriptionfactorthatactivatestargetgenesthroughcAMPresponseelements.CREBisabletomediatesignalsfromnumerousphysiologicalstimuli,resultinginregulationofabroadarrayofcellularresponses.WhileCREBisexpressedinnumeroustissues,itplaysalargeregulatoryroleinthenervoussystem.CREBisbelievedtoplayakeyroleinpromotingneuronalsurvival,precursorproliferation,neuriteoutgrowthandneuronaldifferentiationincertainneuronalpopulations.CREBpromotesoutgrowthanddifferentiationasamediatorofneurotrophinpathways.CREBisabletoselectivelyactivatenumerousdownstreamgenesthroughinteractionswithdifferentdimerizationpartners.CREBisactivatedbyphosphorylationatSer133byvarioussignalingpathwaysincludingErk,Ca2+andstresssignaling.
      ProductInformation
      FormatPurified
      Control
      • Forskolin-stimulatedWI-38nuclearextracts.
      PresentationPurifiedrabbitIgGinbuffercontaining0.1MTris-Glycine(pH7.4)15mMNaCl,and0.05%sodiumazidewith30%glycerol.
      StorageandShippingInformation
      StorageConditionsStablefor1yearat-20°Cfromdateofreceipt.

      HandlingRecommendations:
      Uponreceipt,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.
      Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.
      Applications
      ApplicationUseAnti-phospho-CREB(Ser133)Antibody(rabbitpolyclonalantibody)ishighlypublishedandvalidatedinEMSA,IHC,IHC(P),IP,WBtodetectphospho-CREB(Ser133)alsoknownasactivetranscriptionfactorCREB,cAMPresponsiveelementbindingprotein1.
      KeyApplications
      • ElectrophoreticMobilityShiftAssay
      • Immunohistochemistry
      • Immunohistochemistry(Paraffin)
      • Immunoprecipitation
      • WesternBlotting
      ApplicationNotesImmunoprecipitation:
      10μLofapreviouslotimmunoprecipitatedphosphorylatedCREBfrom500μgofcellstreatedwith50μMforskolin.

      Immunohistochemistry:
      A1:1000dilutionofpreviouslotsdetectedphosphorylatedCREBinformalin-fixedparaffin-embeddednormalandischemicratbrainsections.

      GelShift(EMSA):
      Thisantibodyhasbeenshowntogelshiftbyindependentlabs.
      BIOLOGicalInformation
      ImmunogenKLH-conjugatedsyntheticpeptidecorrespondingtotheaminoacidsincludingandencompassingphosphorylatedSer133ofCREB.
      Epitopephospho-Ser133
      ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
      HostRabbit
      SpecificityRecognizesp43phosphorylatedCREB.Mayalsorecognizep30andp38kDaproteins.Thep30&p38proteinsmaybephosphorylatedCREMandATF-1respectively,sincethetwoproteinssharesignificanthomologytothephosphorylatedCREBimmunizingpeptide.
      IsotypeIgG
      SpeciesReactivity
      • Human
      • Rat
      • Mouse
      • Hamster
      SpeciesReactivityNoteReactswithhuman,hamster,mouseandrat.
      AntibodyTypePolyclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryThisgeneencodesatranscriptionfactorthatisamemberoftheleucinezipperfamilyofDNAbindingproteins.ThisproteinbindsasahomodimertothecAMP-responsiveelement,anoctamericpalindrome.Theproteinisphosphorylatedbyseveralproteinkinases,andinducestranscriptionofgenesinresponsetohormonalstimulationofthecAMPpathway.Alternatesplicingofthisgeneresultsintwotranscriptvariantsencodingdifferentisoforms.
      GeneSymbol
      • CREB1
      • CREB
      • MGC9284
      Modifications
      • Phosphorylation
      PurificationMethodPurifiedbyproteinA-SepharosefollowedbyimmunoadsorbantchromatographyusinganunphosphorylatedCREBaffinitygelcolumn.
      UniProtNumber
      UniProtSummaryFUNCTION:ThisproteinbindsthecAMPresponseelement(CRE),asequencepresentinmanyviralandcellularpromoters.CREBstimulatestranscriptiononbindingtotheCRE.TransciptionactivationisenhancedbytheTORCcoactivatorswhichactindependentlyofSer-133phosphorylation.ImplicatedinsynchronizationofcircADIanrhythmicity.
      SUBUNIT:InteractswithPPRC1.BindsDNAasadimer.ThisdimerisstABIlizedbymagnesiumions.Interacts,throughthebZIPdomain,withthecoactivatorsTORC1/CRTC1,TORC2/CRTC2andTORC3/CRTC3.WhenphosphorylatedonSer-133,bindsCREBBPBysimilarity.
      SUBCELLULAR:Nucleus.
      PMT:Stimulatedbyphosphorylation.PhosphorylationofbothSer-133andSer-142intheSCNregulatestheactivityofCREBandparticipatesincircadianrhythmgeneration.PhosphorylationofSer-133allowsCREBBPbindingBysimilarity.PhosphorylateduponDNAdamage,probablybyATMorATR.
      SIMILARITY:BelongstothebZIPfamily.
      Contains1bZIPdomain.
      Contains1KID(kinase-inducIBLe)domain
      MolecularWeightDetectsCREBonlywhenphosphorylatedonSer133(~43kDa).MayrecognizeATF-1(~38kDa)andCREM(~30kDa)asthetwoproteinssharesignificanthomologytothephosphorylatedimmunizingpeptide.
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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