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Millipore/06-847 | Anti-EGFR Antibody/06-847/200 µg
  • Millipore/06-847 | Anti-EGFR Antibody/06-847/200 µg

Millipore/06-847 | Anti-EGFR Antibody/06-847/200 µg

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貨號(hào): 06-847
品牌: Millipore
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    • Description
      CatalogueNumber06-847
      Replaces04-337;04-338
      BrandFamilyUpstate
      TradeName
      • Upstate
      DescriptionAnti-EGFRAntibody
      AlternateNames
      • Receptortyrosine-proteinkinaseErbB-1
      • avianerythroblasticleukemiaviral(v-erb-b)oncogenehomolog
      • cellgrowthinhibitingprotein40
      • cellproliferation-inducingprotein61
      • epidermalgrowthfactorreceptor
      • epidermalgrowthfactorreceptor(avianerythroblasticleukemiaviral
        (v-erb-b)oncogenehomolog)
      • epidermalgrowthfactorreceptor(erythroblasticleukemiaviral(v-erb-b)oncogenehomolog,avian)
      BackgroundInformationTheepidermalgrowthfactorreceptor(EGFR;ErbB-1;HER1inhumans)isthecell-surfacereceptorformembersoftheepidermalgrowthfactorfamily(EGF-family)ofextracellularproteinligands.TheepidermalgrowthfactorreceptorisamemberoftheErbBfamilyofreceptors,asubfamilyoffourcloselyrelatedreceptortyrosinekinases:EGFR(ErbB-1),HER2/c-neu(ErbB-2),Her3(ErbB-3)andHer4(ErbB-4).MutationsaffectingEGFRexpressionoractivitycouldresultincancer.EGFR(epidermalgrowthfactorreceptor)existsonthecellsurfaceandisactivatedbybindingofitsspecificligands,includingepidermalgrowthfactorandtransforminggrowthfactorα(TGFα).Uponactivationbyitsgrowthfactorligands,EGFRundergoesatransitionfromaninactivemonomericformtoanactivehomodimer.Inadditiontoforminghomodimersafterligandbinding,EGFRmaypairwithanothermemberoftheErbBreceptorfamily,suchasErbB2/Her2/neu,tocreateanactivatedheterodimer.EGFRdimerizationstimulatesitsintrinsicintracellularprotein-tyrosinekinaseactivity.Asaresult,autophosphorylationoffivetyrosine(Y)residuesintheC-terminaldomainofEGFRoccurs.
      ProductInformation
      FormatPurified
      Control
      • A431celllysate,humancervicalcarcinoma.

        IncludedPositiveAntigenControl:
        Catalog#12-305,3T3/A31CellLysate.Add2.5μLof2-mercaptoethanol/100μLoflysateandboilfor5minutestoreducethepreparation.Load20μgofreducedlysateperlaneforminigels.
      PresentationPurifiedrabbitpolyclonalIgGinbuffercontaining0.1MTris-Glycine,0.15MNaCl,0.05%SodiumAzide,pH7.4.Storeat2-8°C.
      StorageandShippingInformation
      StorageConditionsStablefor1yearat2-8°Cfromdateofreceipt.

      HandlingRecommendations:Uponfirstthaw,
      andpriortoremovingthecap,centrifugethe
      vialandgentlymixthesolution.
      Applications
      ApplicationAnti-EGFRAntibodydetectslevelofEGFR&hasbeenpublished&validatedforuseinIP&WB.
      KeyApplications
      • Immunoprecipitation
      • WesternBlotting
      ApplicationNotesImmunoprecipitation:
      4μgofapreviouslotimmunoprecipitatedtheEGFRfrom500μgofa3T3/A31RIPAcelllysate.
      BIOLOGicalInformation
      ImmunogenOvalbuminconjugatedsyntheticpeptide(ETKPNGIFKGPTAENAEYLRVAPPSSEFIGA)correspondingtoaminoacids1156-1186oftheprocessedmouseEGFreceptor(EGFR)C-terminaldomain(AccessionnumberQ01279).Theimmunizingsequenceshares28/31identitywiththehumanEGFreceptorsequence.
      ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
      HostRabbit
      SpecificityRecognizestheEGFR,Mr180kDa.
      IsotypeIgG
      SpeciesReactivity
      • Human
      • Mouse
      • Rat
      • Hamster
      SpeciesReactivityNoteMouseandhuman.Reportedtodetectratandhamster.
      AntibodyTypePolyclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryTheproteinencodedbythisgeneisatransmembraneglycoproteinthatisamemberoftheproteinkinasesuperfamily.Thisproteinisareceptorformembersoftheepidermalgrowthfactorfamily.EGFRisacellsurfaceproteinthatbindstoepidermalgrowthfactor.Bindingoftheproteintoaligandinducesreceptordimerizationandtyrosineautophosphorylationandleadstocellproliferation.Mutationsinthisgeneareassociatedwithlungcancer.[providedbyRefSeq]
      GeneSymbol
      • EGFR
      • ERBB1
      • ERBB
      • mENA
      PurificationMethodProteinAchromatography
      UniProtNumber
      UniProtSummaryFUNCTION:SwissProt:P00533#Isoform2/truncatedisoformmayactasanantagoNIST.
      SIZE:1210aminoacids;134277Da
      SUBUNIT:BindsRIPK1.CBLinteractswiththeautophosphorylatedC-terminaltailoftheEGFreceptor.PartofacomplexwithERBB2andeitherPIK3C2AorPIK3C2B.TheautophosphorylatedforminteractswithPIK3C2B,maybeindirectly.InteractswithPELP1.
      SUBCELLULARLOCATION:Cellmembrane;Single-passtypeImembraneprotein.&Isoform2:Secreted.
      TISSUESPECIFICITY:Expressedinplacenta.Isoform2isalsoexpressedinovariancancers.
      PTM:PhosphorylationofSer-695ispartialandoccursonlyifThr-693isphosphorylated.&MonoubiquitinatedandpolyubiquitinateduponEGFstimulation;whichdoesnotaffecttyrosinekinaseactivityorsignalingcapacitybutmayplayaroleinlysosomaltargeting.Polyubiquitinlinkageismainlythrough"Lys-63",butlinkagethrough"Lys-48","Lys-11"and"Lys-29"alsooccur.DISEASE:SwissProt:P00533#DefectsinEGFRareassociatedwithlungcancer[MIM:211980].
      SIMILARITY:SwissProt:P00533##Belongstotheproteinkinasesuperfamily.Tyrproteinkinasefamily.EGFreceptorsubfamily.&Contains1proteinkinasedomain.
      MISCELLANEOUS:BindingofEGFtothereceptorleadstodimerization,internalizationoftheEGF-receptorcomplex,inductionofthetyrosinekinaseactivity,stimulationofcellDNAsynthesis,andcellproliferation.
      MolecularWeight180kDa
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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