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Millipore/07-1024 | Anti-EGFR Antibody, cytoplasmic domain/07-1024/100 µg
  • Millipore/07-1024 | Anti-EGFR Antibody, cytoplasmic domain/07-1024/100 µg

Millipore/07-1024 | Anti-EGFR Antibody, cytoplasmic domain/07-1024/100 µg

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貨號: 07-1024
品牌: Millipore
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    • Description
      CatalogueNumber07-1024
      DescriptionAnti-EGFRAntibody,cytoplasmicdomain
      AlternateNames
      • Receptortyrosine-proteinkinaseErbB-1
      • avianerythroblasticleukemiaviral(v-erb-b)oncogenehomolog
      • cellgrowthinhibitingprotein40
      • cellproliferation-inducingprotein61
      • epidermalgrowthfactorreceptor
      BackgroundInformationEGFR(EpidermalGrowthFactorReceptor;ErbB-1;HER1)isthecell-surfacereceptorformembersoftheepidermalgrowthfactorfamily(EGF-family)ofextracellularproteinligands.TheEGFreceptorisamemberoftheErbBfamilyofreceptors,asubfamilyoffourcloselyrelatedreceptortyrosinekinases:EGFR(ErbB-1),HER2/c-neu(ErbB-2),Her3(ErbB-3)andHer4(ErbB-4).MutationsaffectingEGFRexpressionoractivitycouldresultincancer.
      EGFRdimerizationstimulatesitsintrinsicintracellularprotein-tyrosinekinaseactivity.Asaresult,autophosphorylationoffivetyrosine(Y)residues(Y992,Y1045,Y1068,Y1148andY1173)intheC-terminaldomainofEGFRoccurs.Thisautophosphorylationelicitsdownstreamactivationandsignalingbyseveralotherproteinsthatassociatewiththephosphorylatedtyrosinesthroughtheirownphosphotyrosine-bindingSH2domains.
      Thesedownstreamsignalingproteinsinitiateseveralsignaltransductioncascades,principallytheMAPK,AktandJNKpathways,leADIngtoDNAsynthesisandcellproliferation.
      ProductInformation
      FormatAffinityPurified
      PresentationAffinitypurifiedrabbitpolyclonalin0.1MTris-Glycine(pH7.4)with150mMNaCland0.05%NaN3.
      StorageandShippingInformation
      StorageConditionsStablefor1yearat2-8°Cfromdateofreceipt.
      HandlingRecommendations:Uponreceipt,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.
      Applications
      ApplicationThisAnti-EGFRAntibody,cytoplasmicdomainisvalidatedforuseinWBforthedetectionofEGFR.
      KeyApplications
      • WesternBlotting
      BIOLOGicalInformation
      ImmunogenGSTfusionproteincorrespondingtothecytoplasmicdomainofhumanEGFR.
      EpitopeCytoplasmicDomain
      ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
      HostRabbit
      SpecificityDetectsEGFR
      SpeciesReactivity
      • Human
      SpeciesReactivityNoteHuman.Otherspecieshavenotbeentested.
      AntibodyTypePolyclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryTheproteinencodedbythisgeneisatransmembraneglycoproteinthatisamemberoftheproteinkinasesuperfamily.Thisproteinisareceptorformembersoftheepidermalgrowthfactorfamily.EGFRisacellsurfaceproteinthatbindstoepidermalgrowthfactor.Bindingoftheproteintoaligandinducesreceptordimerizationandtyrosineautophosphorylationandleadstocellproliferation.Mutationsinthisgeneareassociatedwithlungcancer.[providedbyRefSeq]
      GeneSymbol
      • EC2.7.10.1
      • ERBB
      • ERBB1
      • HER1
      • PIG61
      • mENA
      PurificationMethodImmunogenAffinityPurified
      UniProtNumber
      UniProtSummaryFunction:ReceptorforEGF,butalsoforothermembersoftheEGFfamily,asTGF-alpha,amphiregulin,betacellulin,heparin-bindingEGF-likegrowthfactor,GP30andvacciniavirusgrowthfactor.Isinvolvedinthecontrolofcellgrowthanddifferentiation.PhosphorylatesMUC1inbreastcancercellsandincreasestheinteractionofMUC1withC-SRCandCTNNB1/beta-catenin.Ref.31

      Isoform:2/truncatedisoformmayactasanantagoNIST.Ref.31

      Catalyticactivity:ATP+a[protein]-L-tyrosine=ADP+a[protein]-L-tyrosinephosphate.

      Subunitstructure:BindsRIPK1.CBLinteractswiththeautophosphorylatedC-terminaltailoftheEGFreceptor.PartofacomplexwithERBB2andeitherPIK3C2AorPIK3C2B.TheautophosphorylatedforminteractswithPIK3C2B,maybeindirectly.InteractswithPELP1.BindsMUC1.Ref.31Ref.25Ref.29Ref.30Ref.35

      Subcellularlocation:Cellmembrane;Single-passtypeImembraneprotein.

      Isoform:2:Secreted.

      Tissuespecificity:Ubiquitouslyexpressed.Isoform2isalsoexpressedinovariancancers.Ref.38

      Post-translationalmodification:PhosphorylationofSer-695ispartialandoccursonlyifThr-693isphosphorylated.Ref.16Ref.24Ref.28Ref.32Ref.33Ref.34Ref.36Ref.37Ref.39Ref.40Ref.41Ref.42
      MonoubiquitinatedandpolyubiquitinateduponEGFstimulation;whichdoesnotaffecttyrosinekinaseactivityorsignalingcapacitybutmayplayaroleinlysosomaltargeting.Polyubiquitinlinkageismainlythrough"Lys-63",butlinkagethrough"Lys-48","Lys-11"and"Lys-29"alsooccur.

      Involvementindisease:DefectsinEGFRareassociatedwithlungcancer[MIM:211980].

      Miscellaneous:BindingofEGFtothereceptorleadstodimerization,internalizationoftheEGF-receptorcomplex,inductionofthetyrosinekinaseactivity,stimulationofcellDNAsynthesis,andcellproliferation.

      Sequencesimilarities:Belongstotheproteinkinasesuperfamily.Tyrproteinkinasefamily.EGFreceptorsubfamily.
      Contains1proteinkinasedomain.
      MolecularWeight180kDa
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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