Immunogen | RatGSK3betasyntheticpeptide(aa.335-349),conjugatedtoKLH.Thissequenceis100%identicaltohumanGSK3beta. |
Epitope | a.a.335-349 |
Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
Host | Rabbit |
Specificity | Thisantibodydetectsastrong47kDaprotein,correspondingtotheexpectedmolecularmassofGSK3beta. |
Isotype | IgG |
SpeciesReactivity | |
AntibodyType | PolyclonalAntibody |
EntrezGeneNumber | |
EntrezGeneSummary | Glycogensynthasekinase-3(GSK3)isaproline-directedserine-threoninekinasethatwasinitiallyidentifiedasaphosphorylatingandnactivatingglycogensynthase.Twoisoforms,alpha(GSK3A;MIM606784)andbeta,showahighdegreeofaminoacidhomology(StambolicandWoodgett,1994[PubMed7980435]).GSK3Bisinvolvedinenergymetabolism,neuronalcelldevelopment,andbodypatternformation(Plyteetal.,1992[PubMed1333807]).[suppliedbyOMIM].
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GeneSymbol | |
PurificationMethod | ProteinAaffinitypurified |
UniProtNumber | |
UniProtSummary | FUNCTION:ParticipatesintheWntsignalingpathway.Implicatedinthehormonalcontrolofseveralregulatoryproteinsincludingglycogensynthase,MYBandthetranscriptionfactorJUN.PhosphorylatesJUNatsitesproximaltoitsDNA-bindingdomain,therebyreducingitsaffinityforDNA.PhosphorylatesMUC1inbreastcancercells,anddecreasestheinteractionofMUC1withCTNNB1/beta-catenin. CATALYTICACTIVITY:ATP+[tauprotein]=ADP+[tauprotein]phosphate. ENZYMEREGULATION:InhibitedwhenphosphorylatedbyAKT1. SUBUNIT:Monomer(Bysimilarity).InteractswithCABYR,MUC1,NINandPRUNE. ALTERNATIVEPRODUCTS:2namedisoforms[FASTA]producedbyalternativesplicing. |
MolecularWeight | Thisantibodydetectsastrong47kDaprotein. |