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Millipore/07-1431 | Anti-Tie-2 Antibody, NT/07-1431/50 µg
  • Millipore/07-1431 | Anti-Tie-2 Antibody, NT/07-1431/50 µg

Millipore/07-1431 | Anti-Tie-2 Antibody, NT/07-1431/50 µg

價格: ¥3444.00 市場價: 5740.00

貨號: 07-1431
品牌: Millipore
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    • Description
      CatalogueNumber07-1431
      ReplacesAB3126
      DescriptionAnti-Tie-2Antibody,NT
      AlternateNames
      • CD202bantigen
      • TEKtyrosinekinase,endothelial
      • Tunicainternaendothelialcellkinase
      • Tyrosine-proteinkinasereceptorTEK
      • Tyrosine-proteinkinasereceptorTIE-2
      • p140TEK
      • solubleTIE2variant1
      • solubleTIE2variant2
      • venousmalformations,multiplecutaneousandmucosal
      BackgroundInformationTie-2isamemberofthetyrosineproteinkinasefamily,isatransmembranereceptorforangiopoietin1,andmayrepresentoneoftheearliestMarkersforcelllineagewithinmammalianendothelialcells.Itsexpressionisalmostonlyfoundinhuman,mouseandratendothelialcellsandangioblasts.Mostlikely,Tie-2regulatesthedifferentiation,properdispersal,andproliferationofthesecellsduringangiogenesis.MutationsinTEKareacauseofVMCMordominantlyinheritedvenousmalformationswhicharecharacterizedbyserpiginious,dilatedveins.Tie-2canbefoundinplacentaandlungtissue.Lowerlevelsoftheproteincanalsobefoundinkidney,umbilicalveinendothelialcells,andbrain.
      ProductInformation
      FormatAffinityPurified
      Control
      • Humanbrainlysate
      PresentationAffinitypurifiedimmunoglobulin.Liquidin100mMTris,pH7.5,containing0.2%BSAand0.05%sodiumazide.
      StorageandShippingInformation
      StorageConditionsMaintainat-20°Cinundilutedaliquotsforupto12monthsafterdateofreceipt.Avoidrepeatedfreeze/thawcycles.
      Applications
      ApplicationThisAnti-Tie-2Antibody,N-terminusisvalidatedforuseinWBforthedetectionofTie-2.
      KeyApplications
      • WesternBlotting
      BIOLOGicalInformation
      Immunogen18aminoacidpeptidesequencewithintheextracellular,N-terminusofhumanTie-2
      ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
      HostRabbit
      SpecificityRecognizeshumanTunicainternalendothelialcellkinase(TIE-2),alsodescribedasAngiopoietin-1receptor,p140TEK,ortyrosineproteinkinasereceptor.Thepeptidesequenceusedasimmunogenis100%conservedinhuman,rat,mouse,and94%inbovine.
      SpeciesReactivity
      • Human
      • Mouse
      • Rat
      AntibodyTypePolyclonalAntibody
      EntrezGeneNumber
      GeneSymbol
      • CD202B
      • CD202b
      • EC2.7.10.1
      • OTTHUMP00000021167
      • TIE-2
      • TIE2
      • VMCM
      • VMCM1
      • hTIE2
      PurificationMethodAffinityPurfied
      UniProtNumber
      UniProtSummaryFUNCTION:Thisproteinisaproteintyrosine-kinasetransmembranereceptorforangiopoietin1.Itmayconstitutetheearliestmammalianendothelialcelllineagemarker.Probablyregulatesendothelialcellproliferation,differentiationandguidestheproperpatterningofendothelialcellsduringbloodvesselformation.
      CATALYTICACTIVITY:ATP+a[protein]-L-tyrosine=ADP+a[protein]-L-tyrosinephosphate.
      SUBUNITSTRUCTURE:InteractswithPTPRB.
      SUBCELLULARLOCATION:Membrane;Single-passtypeImembraneprotein.
      TISSUESPECIFICITY:PredominantlyexpressedinendothelialcellsandtheirProgenitors,theangioblasts.Hasbeendirectlyfoundinplacentaandlung,withalowerlevelinumbilicalveinendothelialcells,brainandkidney.
      PTM:Phosphorylated.PhosphorylationisinducedbyANGPT1andANGPT2.ANGPT1-inducedphosphorylationisimpairedduringhypoxia.DephosphorylatedbyPTPRB.
      INVOLVEMENTINDISEASE:DefectsinTEKareacauseofdominantlyinheritedvenousmalformations(VMCM)[MIM:600195];anerrorofvascularmorphogenesischaracterizedbydilated,serpiginouschannels.
      SEQUENCESIMILARITIES:Belongstotheproteinkinasesuperfamily.Tyrproteinkinasefamily.Tiesubfamily.
      Contains3EGF-likedomains.
      Contains3fibronectintype-IIIdomains.
      Contains2Ig-likeC2-type(immunoglobulin-like)domains.
      Contains1proteinkinasedomain.
      MolecularWeightApprox.126kDa
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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