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Millipore/07-1596 | Anti-SIRT3 (CT) Antibody/07-1596/100 µg
  • Millipore/07-1596 | Anti-SIRT3 (CT) Antibody/07-1596/100 µg

Millipore/07-1596 | Anti-SIRT3 (CT) Antibody/07-1596/100 µg

價格: ￥4680.00 市場價: 7800.00
貨號: 07-1596
品牌: Millipore
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    • Description
      CatalogueNumber07-1596
      DescriptionAnti-SIRT3(CT)Antibody
      AlternateNames
      • SIR2-likeprotein3,mitochondrialnicotinamideadeninedinucleotide-dependentdeacetylase
      • silentmatingtypeinformationregulation2,S.cerevisiae,homolog3
      • sir2-like3
      • sirtuin(silentmatingtypeinformationregulation2homolog)3(S.cerevisiae)
      • sirtuin(silentmatingtypeinformationregulation2,S.cerevisiae,homolog)3
      • sirtuin3
      • sirtuintype3
      BackgroundInformationSIRT3isamemberoftheclassIsirtuinfamilyofproteins,homologstotheyeastSir2protein.Membersofthesirtuinfamilyarecharacterizedbyasirtuincoredomainandgroupedintofourclasses.SIRT3islocatedinthemitochondriaandhasbeenimplicatedinregulatingmetabolicprocesses.EndogenousSIRT3isasolubleproteinlocatedinthemitochondrialmatrix.OverexpressionofSirt3inculturedcellsincreasesrespirationanddecreasestheproductionofreactiveoxygenspecies.FastingincreasesSirt3expressioninwhiteandbrownADIposetissue.AlongerformofSIRT3ispresentinthenucleuswhereitexhibitshistonedeacetylaseactivity.SIRT3protectscardiomyocytesfromstressmediatedcelldeathduetodeacetylationofanuclearfactor,Ku-70.
      ProductInformation
      FormatPurified
      Control
      • C2C12celllysate
      PresentationPurifiedrabbitpolyclonalinbuffercontaining0.09%NaN3.
      StorageandShippingInformation
      StorageConditionsStablefor6monthsat2-8°Cfromdateofreceipt.Forlongtermstorage,storeat-20oC.HandlingRecommendations:Uponreceiptandpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.
      Applications
      ApplicationAnti-SIRT3(C-terminus)AntibodyisaRabbitPolyclonalAntibodyfordetectionofSIRT3(C-terminus)alsoknownsirtuin3&hasbeenvalidatedinWB,ELISA&IHC.
      KeyApplications
      • WesternBlotting
      • ELISA
      • Immunohistochemistry
      ApplicationNotesELISA:
      ThisantibodyhasbeenshownbyanoutsidelaboratorytobesuitableforELISA(1:1000).

      Immunohistochemistry:
      Thisantibodyhasbeenshownbyanoutsidelaboratorytobesuitableforhistochemistryusinghumanhepatocarcinomatissue(1:50–1:100).
      BIOLOGicalInformation
      ImmunogenTheimmunogenwasapeptidecorrespondingtheC-terminalregionofhumanSIRT3.
      EpitopeC-terminus
      ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
      HostRabbit
      SpecificityThisantibodyrecognizesSIRT3.Endogenouslevelsofthisproteinvaryamongcelllines;theproteinwaseasilydetectedinRAW264.7andC2C12cellsbutonlyweaklydetectedinHeLacells,andnotdetectedinJurkat,HEK293orPC3cells.
      SpeciesReactivity
      • Mouse
      • Human
      SpeciesReactivityNoteHuman,Mouse.Nottestedinotherspecies.
      AntibodyTypePolyclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryThisgeneencodesamemberofthesirtuinfamilyofproteins,homologstotheyeastSir2protein.Membersofthesirtuinfamilyarecharacterizedbyasirtuincoredomainandgroupedintofourclasses.Thefunctionsofhumansirtuinshavenotyetbeendetermined;however,yeastsirtuinproteinsareknowntoregulateepigeneticgenesilencingandsuppressrecombinationofrDNA.Studiessuggestthatthehumansirtuinsmayfunctionasintracellularregulatoryproteinswithmono-ADP-ribosyltransferaseactivity.TheproteinencodedbythisgeneisincludedinclassIofthesirtuinfamily.Twoalternativelysplicedtranscriptvariantsthatencodedifferentproteinshavebeendescribedforthisgene.[providedbyRefSeq].
      GeneSymbol
      • SIR2L3
      • hSIRT3
      • EC3.5.1
      PurificationMethodPurified
      UniProtNumber
      UniProtSummaryFUNCTION:NAD-dependentdeacetylase.DespitesomeABIlitytodeacetylatehistonesinvitro,itisunlikelyinvivo.

      CatalyticactivityNAD++anacetylprotein=nicotinamide+O-acetyl-ADP-ribose+aprotein.Ref.4Ref.5

      CofactorBinds1zincionpersubunitBysimilarity.

      SUBCELLULARLOCATION:Mitochondrionmatrix.Ref.4Ref.5

      TISSUESPECIFICITY:Widelyexpressed.Ref.5Ref.1

      PTM:Processedbymitochondrialprocessingpeptidase(MPP)togivea28kDaproduct.Suchprocessingisprobablyessentialforitsenzymaticactivity.

      SEQUENCESIMILARITY:Belongstothesirtuinfamily.

      Contains1deacetylasesirtuin-typedomain.

      MolecularWeight44kDa
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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