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Millipore/07-218 | Anti-Notch1 Antibody, extracellular domain/07-218/100 µg
  • Millipore/07-218 | Anti-Notch1 Antibody, extracellular domain/07-218/100 µg

Millipore/07-218 | Anti-Notch1 Antibody, extracellular domain/07-218/100 µg

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貨號: 07-218
品牌: Millipore
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    • Description
      CatalogueNumber07-218
      Replaces04-1046
      BrandFamilyUpstate
      TradeName
      • Upstate
      DescriptionAnti-Notch1Antibody,extracellulardomain
      BackgroundInformationTheNotchproteinfamilyisagroupofhighlyconservedproteinsimportantinthedeterminationofcellfateandmaintenanceofProgenitorsinmanydevelopmentalsystems.Thisfamilyofproteinsfunctionbothasmembranecellreceptorsandastranscriptionfactors.ActivationofNotchbycell-cellinteractionscausesatranscriptioninhibitoryeffectthatenablesinhibitionofdifferentiationinsomecellsbutnotinothers.Asaconsequence,somecellsadoptaparticularfatewhileotherprogenitorsremainuncommitted.TheNotchproteinisimportantincellfateduringmyogenesis,neurogenesis,oogenesis,andwingandeyedevelopmentinDrosophila.Inmammals,fourNotchgeneswereidentified(Notch1-4)thatareexpressedinawidevarietyofcellsandplayacrucialroleindifferentiationanddevelopment.
      ProductInformation
      FormatPurified
      Control
      • L/N17transfectedNotch1celllysate
      PresentationProteinApurifiedimmunoglobulinpresentedin0.1MTris-Glycine,0.15MNaCl,and0.05%SodiumAzide,pH7.4
      StorageandShippingInformation
      StorageConditionsStablefor1yearat2-8°Cfromdateofreceipt.
      Applications
      ApplicationAnti-Notch1Antibody,extracellulardomainisahighqualityRabbitPolyclonalAntibodyforthedetectionofNotch1&hasbeenvalidatedinWB.
      KeyApplications
      • WesternBlotting
      BIOLOGicalInformation
      ImmunogenN-terminalGSTfusionproteincorrespondingtoresidues381-853ofratNotch1
      HostRabbit
      SpecificityNotch1
      IsotypeIgG
      SpeciesReactivity
      • Rat
      • Mouse
      SpeciesReactivityNoteUsedinmouseinthefollowingpublication:Gulino,R.,etal,EuropeanJournalofNeuroscience,Vol.31,pp.1423–1434,2010.
      AntibodyTypePolyclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryThisgeneencodesamemberoftheNotchfamily.MembersofthisType1transmembraneproteinfamilysharestructuralcharacteristicsincludinganextracellulardomainconsistingofmultipleepidermalgrowthfactor-like(EGF)repeats,andanintracellulardomainconsistingofmultiple,differentdomaintypes.Notchfamilymembersplayaroleinavarietyofdevelopmentalprocessesbycontrollingcellfatedecisions.TheNotchsignalingnetworkisanevolutionarilyconservedintercellularsignalingpathwaywhichregulatesinteractionsbetweenphysicallyadjacentcells.InDrosophilia,notchinteractionwithitscell-boundligands(delta,serrate)establishesanintercellularsignalingpathwaythatplaysakeyroleindevelopment.Homologuesofthenotch-ligandshavealsobeenidentifiedinhuman,butpreciseinteractionsbetweentheseligandsandthehumannotchhomologuesremaintobedetermined.Thisproteiniscleavedinthetrans-Golginetwork,andpresentedonthecellsurfaceasaheterodimer.Thisproteinfunctionsasareceptorformembraneboundligands,andmayplaymultiplerolesduringdevelopment.
      GeneSymbol
      • NOTCH1
      • notch1
      • hN1
      • TAN1
      PurificationMethodProteinAchromatography
      UniProtNumber
      UniProtSummaryFUNCTION:SwissProt:P46531#Functionsasareceptorformembrane-boundligandsJagged1,Jagged2andDelta1toregulatecell-fatedetermination.Uponligandactivationthroughthereleasednotchintracellulardomain(NICD)itformsatranscriptionalactivatorcomplexwithRBP-Jkappaandactivatesgenesoftheenhancerofsplitlocus.Affectstheimplementationofdifferentiation,proliferationandapoptoticprograms.Maybeimportantfornormallymphocytefunction.Inalteredform,maycontributetotransformationorprogressioninsomeT-cellneoplasms.InvolvedinthematurationofbothCD4+andCD8+cellsinthethymus.MaybeimportantforfolliculardifferentiationandpossIBLycellfateselectionwithinthefollicle.Duringcerebellardevelopment,mayfunctionasareceptorforneuronalDNERandmaybeinvolvedinthedifferentiationofBergmannglia(Bysimilarity).
      SIZE:2556aminoacids;272500Da
      SUBUNIT:HeterodimerofaC-terminalfragmentN(TM)andanN-terminalfragmentN(EC)whichareprobablylinkedbydisulfidebonds.InteractswithDNER,DTX1,DTX2andRBPSUH.AlsointeractswithMAML1,MAML2andMAML3whichactastranscriptionalcoactivatorsforNOTCH1.
      SUBCELLULARLOCATION:Cellmembrane;Single-passtypeImembraneprotein(Bysimilarity).&Notch1intracellulardomain:Nucleus(Bysimilarity).Note=FollowingproteolyticalprocessingNICDistranslocatedtothenucleus(Bysimilarity).
      TISSUESPECIFICITY:Infetaltissuesmostabundantinspleen,brainstemandlung.Alsopresentinmostadulttissueswhereitisfoundmainlyinlymphoidtissues.
      PTM:Synthesizedintheendoplasmicreticulumasaninactiveformwhichisproteolyticallycleavedbyafurin-likeconvertaseinthetrans-Golginetworkbeforeitreachestheplasmamembranetoyieldanactive,ligand-accessibleform.CleavageresultsinaC-terminalfragmentN(TM)andaN-terminalfragmentN(EC).Followingligandbinding,itiscleavedbyTNF-alphaconvertingenzyme(TACE)toyieldamembrane-associatedintermediatefragmentcallednotchextracellulartruncation(NEXT).Thisfragmentisthencleavedbypresenilindependentgamma-secretasetoreleaseanotch-derivedpeptidecontainingtheintracellulardomain(NICD)fromthemembrane(Bysimilarity).&Phosphorylated(Bysimilarity).
      DISEASE:SwissProt:P46531#NOTCH1truncationisassociatedwithT-cellacutelymphoblasticleukemia.&DefectsinNOTCH1areacauseofaorticvalvedisease[MIM:109730].Thedisorderconsistsofanearlydevelopmentaldefectintheaorticvalveandalaterde-repressionofcalciumdepositionthatcausesprogressiveaorticvalvedisease.CalcificationoftheaorticvalveisthethirdleADIngcauseofheartdiseaseinadults.Theincidenceincreaseswithage,anditisoftenassociatedwithabicUSPidaorticvalvepresentin1-2%ofthepopulation.
      SIMILARITY:SwissProt:P46531##BelongstotheNOTCHfamily.&Contains5ANKrepeats.&Contains36EGF-likedomains.&Contains3LNR(Lin/Notch)repeats.
      MolecularWeight260kDa
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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