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Millipore/07-564 | Anti-acetyl-Histone H2B (Lys120) Antibody/07-564/100 µL
  • Millipore/07-564 | Anti-acetyl-Histone H2B (Lys120) Antibody/07-564/100 µL

Millipore/07-564 | Anti-acetyl-Histone H2B (Lys120) Antibody/07-564/100 µL

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貨號: 07-564
品牌: Millipore
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    • Description
      Catalogue Number07-564
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-acetyl-Histone H2B (Lys120) Antibody
      Alternate Names
      • H2BK120Ac
      • Histone H2B (acetyl K120)
      Product Information
      FormatAffinity Purified
      Presentation50mM Tris-glycine, pH 8.0 containing 0.05% sodium azide and 30% glycerol
      Storage and Shipping Information
      Storage Conditions1 year at -20°C
      Applications
      ApplicationUse Anti-acetyl-Histone H2B (Lys120) Antibody (Rabbit Polyclonal Antibody) validated in DB, WB, PIA to detect acetyl-Histone H2B (Lys120) also known as H2BK120Ac, Histone H2B (acetyl K120).
      Key Applications
      • Dot Blot
      • Western Blotting
      • Peptide Inhibition Assay
      Biological Information
      ImmunogenPeptide containing the sequence VTacKYT in which acK corresponds to acetylated lysine 120 of human histone H2B.
      HostRabbit
      SpecificityHistone H2B acetylated on lysine 120
      IsotypeIgG
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryHistones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene contain a palindromic termination element.
      Gene Symbol
      • HIST3H2BB
      Modifications
      • Acetylation
      Purification MethodImmunoAffinity Purified
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q8N257 # Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
      SIZE: 126 amino acids; 13908 Da
      SUBUNIT: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
      SUBCELLULAR LOCATION: Nucleus.
      PTM: Monoubiquitination of Lys-121 by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. & Phosphorylated on Ser-15 by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation. Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class- switch recombination.
      SIMILARITY: SwissProt: Q8N257 ## Belongs to the histone H2B family.
      Molecular Weight~15kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Materials Information
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