Immunogen | 6His-taggedfusionproteincorrespondingtoresidues1031-1215ofhumanhistonedeacetylase6(HDAC6). |
Host | Rabbit |
Specificity | HDAC6 |
Isotype | IgG |
SpeciesReactivity | |
AntibodyType | PolyclonalAntibody |
EntrezGeneNumber | |
EntrezGeneSummary | Histonesplayacriticalroleintranscriptionalregulation,cellcycleprogression,anddevelopmentalevents.Histoneacetylation/deacetylationalterschromosomestructureandaffectstranscriptionfactoraccesstoDNA.TheproteinencodedbythisgenebelongstoclassIIofthehistonedeacetylase/acuc/aphafamily.Itcontainsaninternalduplicationoftwocatalyticdomainswhichappeartofunctionindependentlyofeachother.Thisproteinpossesseshistonedeacetylaseactivityandrepressestranscription. |
GeneSymbol | - HDAC6
- FLJ16239
- JM21
- ORFNames=JM21
- HD6
- KIAA0901
|
PurificationMethod | ProteinAPurfied |
UniProtNumber | |
UniProtSummary | FUNCTION:SwissProt:Q9UBN7#ResponsIBLeforthedeacetylationoflysineresiduesontheN-terminalpartofthecorehistones(H2A,H2B,H3andH4).Histonedeacetylationgivesatagforepigeneticrepressionandplaysanimportantroleintranscriptionalregulation,cellcycleprogressionanddevelopmentalevents.Histonedeacetylasesactviatheformationoflargemultiproteincomplexes(Bysimilarity).Playsacentralroleinmicrotubule-dependentcellmotilityviadeacetylationoftubulin. SIZE:1215aminoacids;131431Da SUBUNIT:InteractswithCBFA2T3,HDAC11andSIRT2.InteractswithF-actin. SUBCELLULARLOCATION:Nucleus.Cytoplasm.Note=Itismainlycytoplasmic,whereitisassociatedwithmicrotubules. PTM:Ubiquitinated.Itspolyubiquitinationhoweverdoesnotleadtoitsdegradation.&Sumoylatedinvitro. SIMILARITY:SwissProt:Q9UBN7##Belongstothehistonedeacetylasefamily.Type2subfamily.&Contains1UBP-typezincfinger. |
MolecularWeight | 134kDa |