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Millipore/09-310 | Anti-phospho-EGFR (Tyr1069) Antibody/09-310/100 µL
  • Millipore/09-310 | Anti-phospho-EGFR (Tyr1069) Antibody/09-310/100 µL

Millipore/09-310 | Anti-phospho-EGFR (Tyr1069) Antibody/09-310/100 µL

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貨號(hào): 09-310
品牌: Millipore
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    • Description
      CatalogueNumber09-310
      Replaces04-339
      DescriptionAnti-phospho-EGFR(Tyr1069)Antibody
      AlternateNames
      • Receptortyrosine-proteinkinaseErbB-1
      • avianerythroblasticleukemiaviral(v-erb-b)oncogenehomolog
      • cellgrowthinhibitingprotein40
      • cellproliferation-inducingprotein61
      • epidermalgrowthfactorreceptor
      • epidermalgrowthfactorreceptor(avianerythroblasticleukemiaviral(v-erb-b)oncogenehomolog)
      • epidermalgrowthfactorreceptor(erythroblasticleukemiaviral(v-erb-b)oncogenehomolog,avian)
      BackgroundInformationEGFR(Epidermalgrowthfactorreceptor,ErbB-1)isareceptortyrosinekinase(RTK)thatisoneoffourmembersoftheEGFR/ErbBfamilyofreceptortyrosinekinases.EGFRplaysakeyroleintheregulationofessentialnormalcellularprocessesandinthepathophysiologyofhyperproliferativediseasessuchascancer.ActivationoftheEGFRsignalingpathwayhasbeenlinkedwithincreasedcellproliferation,angiogenesis,metastasisanddecreasedapoptosis.Uponligandbinding,EGFRundergoesatransitionfromaninactivemonomericformtoanactivedimer.Inadditiontoforminghomodimers,EGFRmaypairwithanothermemberoftheErbBreceptorfamily,suchasErbB2/Her2/neu,tocreateanactivatedheterodimer.EGFRdimerizationstimulatesitsintrinsicintracellularprotein-tyrosinekinaseactivitythatleadstotrans-andauto-phosphorylationoftyrosineresidueswithinthecytoplasmicdomainofthereceptortyrosinekinaseoffivetyrosine(Y)residuesonsitesY992,Y1045,Y1068,Y1148andY1173locatedontheC-terminaldomainofEGFR.Thisautophosphorylationelicitsdownstreamactivationofseveralsignaltransductioncascades,principallytheMAPK,AktandJNKpathwaysthroughRas,PI3Kinase,andPLCpathwaysthatultimatelyleadstotheactivationofthevariouspathwaysdownstream.Tyr1069isphosphorylatedduringactivation.
      ProductInformation
      FormatAffinityPurified
      Control
      • UntreatedandEGFtreatedA431lysates
      PresentationAntigenaffinitypurifiedrabbitpolyclonalin0.1MTris-Glycine(pH7.4)150mMNaCl,with0.05%sodiumazide.
      StorageandShippingInformation
      StorageConditionsStablefor1yearat2-8oCinundilutedaliquotsfromdateofreceipt.
      HandlingRecommendations:Uponreceipt,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.
      Applications
      ApplicationThisAnti-phospho-EGFR(Tyr1069)AntibodyisvalidatedforuseinELISA,IC,WBforthedetectionofphospho-EGFR(Tyr1069).
      KeyApplications
      • ELISA
      • Immunocytochemistry
      • WesternBlotting
      ApplicationNotesImmunofluroescentImmunocytochemistry:
      BIOLOGicalInformation
      ImmunogenTyrosine-phosphorylatedepidermalgrowthfactorreceptor.
      EpitopeTyr1069(cytoplasmicdomain)
      HostRabbit
      SpecificityReactsstronglyandspecificallywithTyr1069phosphorylatedEGFR
      SpeciesReactivity
      • Human
      • Mouse
      • Pig
      • Primate
      • Horse
      • Rat
      SpeciesReactivityNoteTestedinHuman.Expectedtoreactwithmouse,rat,primate,horseandpigbasedon100%sequencehomology.
      AntibodyTypePolyclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryTheproteinencodedbythisgeneisatransmembraneglycoproteinthatisamemberoftheproteinkinasesuperfamily.Thisproteinisareceptorformembersoftheepidermalgrowthfactorfamily.EGFRisacellsurfaceproteinthatbindstoepidermalgrowthfactor.Bindingoftheproteintoaligandinducesreceptordimerizationandtyrosineautophosphorylationandleadstocellproliferation.Mutationsinthisgeneareassociatedwithlungcancer.[providedbyRefSeq]
      GeneSymbol
      • ERBB
      • ERBB1
      • HER1
      • PIG61
      • mENA
      • EC2.7.10.1
      Modifications
      • Phosphorylation
      PurificationMethodAntigenAffinityPurified
      UniProtNumber
      UniProtSummaryFUNCTION:ReceptorforEGF,butalsoforothermembersoftheEGFfamily,asTGF-alpha,amphiregulin,betacellulin,heparin-bindingEGF-likegrowthfactor,GP30andvacciniavirusgrowthfactor.Isinvolvedinthecontrolofcellgrowthanddifferentiation.PhosphorylatesMUC1inbreastcancercellsandincreasestheinteractionofMUC1withC-SRCandCTNNB1/beta-catenin.Ref.32

      Isoform2/truncatedisoformmayactasanantagoNIST.Ref.32

      CatalyticactivityATP+a[protein]-L-tyrosine=ADP+a[protein]-L-tyrosinephosphate.

      SUBUNIT:BindsRIPK1.CBLinteractswiththeautophosphorylatedC-terminaltailoftheEGFreceptor.PartofacomplexwithERBB2andeitherPIK3C2AorPIK3C2B.TheautophosphorylatedforminteractswithPIK3C2B,maybeindirectly.InteractswithPELP1.BindsMUC1.Ref.32Ref.26Ref.30Ref.31Ref.36

      SUBCELLULARLOCATION:Cellmembrane;Single-passtypeImembraneprotein.

      Isoform2:Secreted.

      TISSUESPECIFICITY:Ubiquitouslyexpressed.Isoform2isalsoexpressedinovariancancers.Ref.39

      PTM:PhosphorylationofSer-695ispartialandoccursonlyifThr-693isphosphorylated.Ref.17Ref.25Ref.29Ref.33Ref.34Ref.35Ref.37Ref.38Ref.40Ref.41Ref.42Ref.43

      MonoubiquitinatedandpolyubiquitinateduponEGFstimulation;whichdoesnotaffecttyrosinekinaseactivityorsignalingcapacitybutmayplayaroleinlysosomaltargeting.Polyubiquitinlinkageismainlythrough"Lys-63",butlinkagethrough"Lys-48","Lys-11"and"Lys-29"alsooccur.

      DISEASE:DefectsinEGFRareassociatedwithlungcancer[MIM:211980].

      MiscellaneousBindingofEGFtothereceptorleadstodimerization,internalizationoftheEGF-receptorcomplex,inductionofthetyrosinekinaseactivity,stimulationofcellDNAsynthesis,andcellproliferation.

      SIMILARITY:Belongstotheproteinkinasesuperfamily.Tyrproteinkinasefamily.EGFreceptorsubfamily.

      Contains1proteinkinasedomain.

      MolecularWeight~170kDa
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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