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  • avanti polar lipids/DSPE-PEG(2000)-DBCO/100mg/880229P-100mg

avanti polar lipids/DSPE-PEG(2000)-DBCO/100mg/880229P-100mg

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    • 880229 | DSPE-PEG(2000)-DBCO

      1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[dibenzocyclooctyl(polyethylene glycol)-2000] (ammonium salt)

      DSPE-PEG(2000)-DBCO
      Info

      DSPE-PEG(2000)-DBCO

      1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[dibenzocyclooctyl(polyethylene glycol)-2000] (ammonium salt)

      Cu-free click chemistry with readily synthesized biarylazacyclooctynones. The reaction of azides with strained alkynes, such as cyclooctynes, readily forms a triazole product without the need for a toxic catalyst.
      Refer also to DSPE-PEG Azide Avanti Number 880228

      Representative Structure

      The molecular weight and exact mass are averages based on the polydispersity of PEG.

      Data
      Hygroscopic
      Yes
      Light Sensitive
      No
      Molecular Formula

      C151H279N4O56P (average MW due to polydispersity of PEG)

      Percent Composition

      C 58.93%, H 9.14%, N 1.82%, O 29.11%, P 1.01%

      Purity
      >99%
      Stability
      1 Year
      Storage Temperature
      -20°C
      CAS Number
      2052955-83-4 CAS Registry Number is a Registered Trademark of the American Chemical Society
      FormulaWeight
      3077.839
      Exact Mass
      3075.884
      Synonyms
      1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[carbonyl-amino(polyethylene glycol)-2000-N’-(succinylazadibenzocyclooctyne)] (ammonium salt)
      Downloads
      • ChemDraw File
      • 3D Structure
      • Structure
      • Safety Data Sheet
      References

      Wong P, Li L, Chea J, Hu W, Poku E, Ebner T, Bowles N, Wong JYC, Yazaki PJ, Sligar S, Shively JE. Antibody Targeted PET Imaging of 64Cu-DOTA-Anti-CEA PEGylated Lipid Nanodiscs in CEA Positive Tumors. Bioconjug Chem. 2020 Jan 30:10.1021/acs.bioconjchem.9b00854. doi: 10.1021/acs.bioconjchem.9b00854. Epub ahead of print. PMID: 31961138.

      PubMed ID: 31961138

      Umlauf BJ, Clark PA, Lajoie JM, Georgieva JV, Bremner S, Herrin BR, Kuo JS, Shusta EV. Identification of variable lymphocyte receptors that can target therapeutics to pathologically exposed brain extracellular matrix. Sci Adv. 2019 May 15;5(5):eaau4245. doi: 10.1126/sciadv.aau4245. eCollection 2019 May.

      PubMed ID: 31106264

      Gupta A, Shin JH, Lee MS, Park JY, Kim K, Kim JH, Suh M, Park CR, Kim YJ, Song MG, Jeong JM, Lee DS, Lee YS, Lee JS. Voxel-Based Dosimetry of Iron Oxide Nanoparticle-Conjugated 177Lu-Labeled Folic Acid Using SPECT/CT Imaging of Mice. Mol Pharm. 2019 Apr 1;16(4):1498-1506. doi: 10.1021/acs.molpharmaceut.8b01125. Epub 2019 Mar 18.

      PubMed ID: 30821463

      Jewett JC, Sletten EM, Bertozzi CR. Rapid Cu-free click chemistry with readily synthesized biarylazacyclooctynones. J Am Chem Soc. 2010 Mar 24;132(11):3688-90. doi: 10.1021/ja100014q.

      PubMed ID: 20187640

      Whitehead SA, McNitt CD, Mattern-Schain SI, Carr AJ, Alam S, Popik VV, Best MD. Artificial Membrane Fusion Triggered by Strain-Promoted Alkyne-Azide Cycloaddition. Bioconjug Chem. 2017 Apr 19;28(4):923-932. doi: 10.1021/acs.bioconjchem.6b00578. Epub 2017 Mar 14.

      PubMed ID: 28248084
      Certificates of Analysis
      • Certificate of Analysis(Lot No. 880229P-100MG-A-013and 6308PLA013)
      • Certificate of Analysis(Lot No. 880229P-10MG-A-013and 6308PIA013)
      • Certificate of Analysis(Lot No. 880229P-25MG-A-013and 6308PJA013)
      • Certificate of Analysis(Lot No. 880229P-50MG-A-013and 6308PKA013)
      • Certificate of Analysis(Lot No. 880229P-10MG-A-014and 6308PIA014)
      • Certificate of Analysis(Lot No. 880229P-25MG-B-013and 6308PJB013)
      • Certificate of Analysis(Lot No. 880229P-50MG-B-013and 6308PKB013)
      • Certificate of Analysis(Lot No. 880229P-100MG-A-014and 6308PLA014)
      • Certificate of Analysis(Lot No. 880229P-25MG-A-014and 6308PJA014)
      • Certificate of Analysis(Lot No. 880229P-50MG-A-014and 6308PKA014)
      • Certificate of Analysis(Lot No. 880229P-10MG-B-014and 6308PIB014)
      • Certificate of Analysis(Lot No. 880229P-100MG-B-014and 6308PLB014)
      • Certificate of Analysis(Lot No. 880229P-10MG-C-014and 6308PIC014)
      • Certificate of Analysis(Lot No. 880229P-100MG-C-014and 6308PLC014)
      • Certificate of Analysis(Lot No. 880229P-25MG-A-015and 6308PJA015)
      • Certificate of Analysis(Lot No. 880229P-50MG-A-015and 6308PKA015)
      • Certificate of Analysis(Lot No. 880229P-25MG-B-015and 6308PJB015)
      • Certificate of Analysis(Lot No. 880229P-10MG-A-015and 6308PIA015)
      • Certificate of Analysis(Lot No. 880229P-10MG-C-015and 6308PIC015)
      • Certificate of Analysis(Lot No. 880229P-50MG-B-015and 6308PKB015)
      • Certificate of Analysis(Lot No. 880229P-50MG-C-015and 6308PKC015)
      • Certificate of Analysis(Lot No. 880229P-25MG-C-015and 6308PJC015)
      • Certificate of Analysis(Lot No. 880229P-50MG-D-015and 6308PKD015)
      • Certificate of Analysis(Lot No. 880229P-100MG-A-016and 6308PLA016)
      • Certificate of Analysis(Lot No. 880229P-100MG-B-016and 6308PLB016)
      • Certificate of Analysis(Lot No. 880229P-25MG-A-016and 6308PJA016)
      • Certificate of Analysis(Lot No. 880229P-10MG-B-016and 6308PIB016)
      • Certificate of Analysis(Lot No. 880229P-50MG-C-016and 6308PKC016)
      • Certificate of Analysis(Lot No. 880229P-25MG-B-016and 6308PJB016)
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