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avanti polar lipids/MVL5/5mg/890000P-5mg

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    • 890000 | MVL5

      N1-[2-((1S)-1-[(3-aminopropyl)amino]-4-[di(3-amino-propyl)amino]butylcarboxamido)ethyl]-3,4-di[oleyloxy]-benzamide

      MVL5
      Info

      MVL5

      N1-[2-((1S)-1-[(3-aminopropyl)amino]-4-[di(3-amino-propyl)amino]butylcarboxamido)ethyl]-3,4-di[oleyloxy]-benzamide

      New Multivalent Cationic Lipid for siRNA Delivery
      ? Improved total gene silencing? Lower non-specific gene silencing? Lower toxicity
      These attributes establish the multivalent MVL5 as a superior transfection vector for siRNAs, and have implications for the optimal use of cationic lipids in therapeutic applications.
      Now available as a pre-mixed kit, MVL5 and GMO ready to use.Avanti Number 640009
      Data
      Hygroscopic
      No
      Light Sensitive
      No
      Molecular Formula
      C59H116Cl5N7O4
      Percent Composition
      C 60.83%, H 10.04%, Cl 15.22%, N 8.42%, O 5.49%
      Purity
      >99%
      Stability
      1 Year
      Storage Temperature
      -20°C
      CAS Number
      464926-03-2 CAS Registry Number is a Registered Trademark of the American Chemical Society
      FormulaWeight
      1164.862
      Exact Mass
      1161.754
      Synonyms
      N1,N1,N4-tris(3-ammoniopropyl)-5-((2-(3,4-bis((Z)-octadec-9-en-1-yloxy)benzamido)ethyl)amino)-5-oxopentane-1,4-diaminium chloride
      Downloads
      • ChemDraw File
      • 3D Structure
      • Structure
      • Safety Data Sheet
      References

      Ravi V, Madhankumar AB, Abraham T, Slagle-Webb B, Connor JR. Liposomal delivery of ferritin heavy chain 1 (FTH1) siRNA in patient xenograft derived glioblastoma initiating cells suggests different sensitivities to radiation and distinct survival mechanisms. PLoS One. 2019 Sep 6;14(9):e0221952. doi: 10.1371/journal.pone.0221952. eCollection 2019.

      PubMed ID: 31491006

      Guevara ML, Jilesen Z, Stojdl D, Persano S. Codelivery of mRNA with α-Galactosylceramide Using a New Lipopolyplex Formulation Induces a Strong Antitumor Response upon Intravenous Administration. ACS Omega. 2019 Aug 7;4(8):13015-13026. doi: 10.1021/acsomega.9b00489. eCollection 2019 Aug 20.

      PubMed ID: 31460428

      Chan CL, Ewert KK, Majzoub RN, Hwu YK, Liang KS, Leal C, Safinya CR. Optimizing cationic and neutral lipids for efficient gene delivery at high serum content. J Gene Med. 2014 Mar-Apr;16(3-4):84-96. doi: 10.1002/jgm.2762.

      PubMed ID: 24753287

      Leal C, Ewert KK, Shirazi RS, Bouxsein NF, Safinya CR. Nanogyroids incorporating multivalent lipids: enhanced membrane charge density and pore forming ability for gene silencing. Langmuir. 2011 Jun 21;27(12):7691-7. doi: 10.1021/la200679x. Epub 2011 May 25.

      PubMed ID: 21612245

      Bouxsein NF, McAllister CS, Ewert KK, Samuel CE, Safinya CR. Structure and gene silencing activities of monovalent and pentavalent cationic lipid vectors complexed with siRNA. Biochemistry. 2007 Apr 24;46(16):4785-92. Epub 2007 Mar 29.

      PubMed ID: 17391006

      Ewert K, Ahmad A, Evans HM, Schmidt HW, Safinya CR. Efficient synthesis and cell-transfection properties of a new multivalent cationic lipid for nonviral gene delivery. J Med Chem. 2002 Nov 7;45(23):5023-9.

      PubMed ID: 12408712
      Certificates of Analysis
      • Certificate of Analysis(Lot No. 890000P-1MG-A-010and 6343PGA010)
      • Certificate of Analysis(Lot No. 890000P-1MG-B-010and 6343PGB010)
      • Certificate of Analysis(Lot No. 890000P-1MG-D-010and 6343PGD010)
      • Certificate of Analysis(Lot No. 890000P-1MG-E-010and 6343PGE010)
      • Certificate of Analysis(Lot No. 890000P-10MG-A-010and 6343PIA010)
      • Certificate of Analysis(Lot No. 890000P-1MG-F-010and 6343PGF010)
      • Certificate of Analysis(Lot No. 890000P-1MG-G-010and 6343PGG010)
      • Certificate of Analysis(Lot No. 890000P-5MG-A-011and 6343PHA011)
      • Certificate of Analysis(Lot No. 890000P-5MG-A-012and 6343PHA012)
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