Immunogen | GSTfusionproteinfromratstargazin,cytoplasmicdomain. |
Host | Rabbit |
Specificity | Stargazin[Stargazin-likeTARP(transmembraneAMPAreceptorregulatoryprotein)].ByWesternblottheantibodyrecognizesbandsat~35kDaand~55kDaonTritonsolublefractionofratbrain.TheantibodyreactsdominantlywithTARPgamma-8andweaklywithgamma-3andgamma-4.Stargazinisexpressedstronglyinthehippocampusandcerebellum. |
SpeciesReactivity | |
AntibodyType | PolyclonalAntibody |
EntrezGeneNumber | |
EntrezGeneSummary | L-typecalciumchannelsarecomposedoffivesubunits.Theproteinencodedbythisgenerepresentsoneofthesesubunits,gamma,andisoneofseveralgammasubunitproteins.Itisanintegralmembraneproteinthatisthoughttostabilizethecalciumchannelinaninactive(closed)state.Thisproteinissimilartothemousestargazinprotein,mutationsinwhichhavebeenassociatedwithabsenceseizures,alsoknownaspetit-malorspike-waveseizures.ThisgeneisamemberoftheneuronalcalciumchannelgammasubunitgenesubfamilyofthePMP-22/EMP/MP20family. |
GeneSymbol | - CACNG2
- stargazin
- MGC138504
- MGC138502
|
PurificationMethod | ImmunoAffinityPurified |
UniProtNumber | |
UniProtSummary | FUNCTION:SwissProt:Q9Y698#Thoughttostabilizethecalciumchannelinaninactivated(closed)state. SIZE:323aminoacids;35966Da SUBUNIT:TheL-typecalciumchanneliscomposedoffivesubunits:alpha-1,alpha-2/delta,betaandgamma.InteractswiththePDZdomainsofDLG4/PSD-95andDLG1/SAP97.MayinteractwithGOPC(Bysimilarity). SUBCELLULARLOCATION:Membrane;Multi-passmembraneprotein. TISSUESPECIFICITY:Brain. PTM:PhosphorylationofThr-321impairsinteractionwithDLG1andDLG4. SIMILARITY:SwissProt:Q9Y698##BelongstothePMP-22/EMP/MP20family.CACNGsubfamily. |