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Millipore/ABS44 | Anti-MAPK 1/2 Antibody/ABS44/100 µg
  • Millipore/ABS44 | Anti-MAPK 1/2 Antibody/ABS44/100 µg

Millipore/ABS44 | Anti-MAPK 1/2 Antibody/ABS44/100 µg

價(jià)格: ￥3324.00 市場價(jià): 5540.00
貨號(hào): ABS44
品牌: Millipore
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    • Description
      CatalogueNumberABS44
      Replaces06-182
      DescriptionAnti-MAPK1/2Antibody
      AlternateNames
      • ERK-1
      • ERT2
      • Extracellularsignal-regulatedkinase1
      • Insulin-stimulatedMAP2kinase
      • MAPkinase3
      • MAPkinaseisoformp44
      • MAPK3
      • Microtubule-associatedprotein2kinase
      • Mitogen-activatedproteinkinase3
      • MNK1
      • p44-ERK1
      • p44-MAPK
      • ERK-2
      • ERT1
      • Extracellularsignal-regulatedkinase2
      • MAPkinase1
      • MAPkinase2
      • MAPkinaseisoformp42
      • MAPK1
      • MAPK2
      • Mitogen-activatedproteinkinase1
      • Mitogen-activatedproteinkinase2
      • p42-MAPK
      BackgroundInformationMitogen-activatedproteinkinase3(EC2.7.11.24;UniProtP21708;alsoknownasERK-1,ERT2,Extracellularsignal-regulatedkinase1,Insulin-stimulatedMAP2kinase,MAPkinase3,MAPkinaseisoformp44,MAPK3,Microtubule-associatedprotein2kinase,MNK1,p44-ERK1,p44-MAPK)isencodedbytheMapk3(alsoknownasErk1,Prkm3)gene(GeneID50689)inratspecies.ERK1(a.k.a.MAPK3)andERK2(a.k.a.MAPK1orMAPK2)arerelatedserine/threoninekinasesoftheRas-Raf-MEK-ERKsignalingpathway.ERK1/2areactivatedbyMEK1/2-catalyzedphosphorylationattheirconservedThr-Glu-Tyr(TEY)dualphosphorylationmotif,firstattheTyrresidue(human/ratERK1Tyr204/Tyr203,human/ratERK2Tyr187/Tyr183)andthenattheThrresidue(human/ratERK1Thr202/Thr201,human/ratERK2Thr185/Thr181).ERK1/2areproline-directedkinasesthatpreferentiallycatalyzethephosphorylationofPro-Xxx-Ser/Thr-Prosequencemotifinhundredsofcytoplasmicandnuclearsubstrates,includingtranscriptionfactorssuchasEts,Elk,andc-Fos.Besidesthisprimarystructurerequirement,manyERK1/2substratespossessaD-dockingsiteand/oranF-dockingsite.Avarietyofscaffoldproteins,includingKSR1/2,IQGAP1,MP1,andβ-Arrestin1/2,alsoparticipateintheregulationofERK1/2MAPkinasecascade.Ras-Raf-MEK-ERKsignalingactivityisupregulatedinaboutone-thirdofallhumancancers,andtargetedinhibitionagainstcomponentsofthissignalingpathwayrepresentsapopularanticancerstrategy.
      ProductInformation
      FormatPurified
      Control
      • A431celllysate
      PresentationPurifiedrabbitpolyclonalinbuffercontaining0.1MTris-Glycine(pH7.4),150mMNaClwith0.05%sodiumazide.
      StorageandShippingInformation
      StorageConditionsStablefor1yearat2-8°Cfromdateofreceipt.
      Applications
      ApplicationDetectMAPK3/MAPK1(ERK1/ERK2)usingthisAnti-MAPK1/2AntibodyvalidatedforuseinImmunocytochemistry,Immunoprecipitation,andWesternBlotting.
      KeyApplications
      • WesternBlotting
      • Immunoprecipitation
      • Immunocytochemistry
      ApplicationNotesWesternBlottingAnalysis:0.5μg/mLfromarepresentativelotdetectedMAPK3/MAPK1(ERK1/ERK2)inBALB/3T3,A431,andL6celllysates.



      WesternBlotting(SNAPID)Analysis:1-2μg/mLfromarepresentativelotdetectedMAPK3/MAPK1(ERK1/ERK2)inBALB/3T3,A431,andL6celllysates.



      ImmunocytochemistryAnalysis:A1:500dilutionfromarepresentativelotdetectedMAPK3/MAPK1(ERK1/ERK2)inNIH/3T3,A431,HeLa,andC2C12cells.
      BIOLOGicalInformation
      ImmunogenKLH-conjugatedlinearpeptidecorrespondingtotheC-terminalsequenceofratMAPK3(ERK-1).
      EpitopeC-terminal
      ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
      HostRabbit
      SpecificityThisantibodyrecognizesMAPK3/MAPK1(ERK1/ERK2)C-terminalsequence.
      SpeciesReactivity
      • Rat
      • Mouse
      • Human
      SpeciesReactivityNoteReactswithhuman,mouse,andrat.Expectedtoreactwithbovineandcaninebasedon94%sequencehomology.
      AntibodyTypePolyclonalAntibody
      EntrezGeneNumber
      GeneSymbol
      • Erk1
      • Erk2
      • Mapk
      • Mapk1
      • Mapk3
      • Prkm1
      • Prkm3
      PurificationMethodProteinApurfied.
      UniProtNumber
      MolecularWeight~44/42kDaobserved.41.26/36.30kDa(humanMAPK1isoform1/2),41.14kDa(ratMAPK1),41.14kDa(mouseMAPK1),43.00/38.14kDa(humanMAPK3isoform1/2),42.95/45.64kDa(ratMAPK3isoform1/2),42.93kDa(mouseMAPK3)calculated(Met1removed).TargetsequenceisnotpresentinhumanMAPK3splicedisoform3(ERK1b).
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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