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Millipore/ECM460 | αVβ3/PECAM Investigator Kit/ECM460/1 kit
  • Millipore/ECM460 | αVβ3/PECAM Investigator Kit/ECM460/1 kit

Millipore/ECM460 | αVβ3/PECAM Investigator Kit/ECM460/1 kit

價格: ￥5724.00 市場價: 9540.00
貨號: ECM460
品牌: Millipore
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    • Description
      CatalogueNumberECM460
      BrandFamilyChemicon®
      TradeName
      • Chemicon
      DescriptionαVβ3/PECAMInvestigatorKit
      OverviewChemiconInvestigatorKitsforIntegrinResearchareacost-effectivesourceofreagentsforallinvestigatorsinvolvedwiththisrapidlyexpandingfieldofstudy.ThealphaVbeta3/PECAMIntegrinInvestigatorKitisdesignedforresearchfocusedonthepresenceofthehumanalphaVbeta3integrinsubunitonPECAM-1[CD31]expressingcells.ThealphaVbeta3/PECAMIntegrinInvestigatorKitcontains100mgeachofCy5-conjugatedmouseanti-integrinalphaVbeta3andFluorescein-conjugatedmouseanti-PECAM-1[CD31]monoclonalantibodies.

      Integrinsbelongtoalargefamilyofcellsurfaceproteinscommonlyreferredtoasglycoproteins.Integrinsarecomposedofnoncovalentlyassociatedalphaandbetasubunitswhichmakeupheterodimers:thelargertermedalphachainandthesmallerbetachain.Atleast16alphasubunitsand8betasubunitsareexpressed,whichcangiveriseto22differentintegrins.Integrinsarethoughttoplaycriticalrolesincellmigration,differentiation,andsurvival.Thereisnowconsiderableevidencethatthesetransmembranereceptorsplayanimportantroleintheregulationofgeneexpressionandsignaltransduction.Excellentreviewsofintegrinstructure,function,andligandspecificitymaybefoundin:Hynes,R.1992.Cell69:11-25;Kramer,R.1993."IntegrinStructureandLigandSpecificityinCell-MatrixInteractions"inMolecularandCellularAspectsofBasementMembranes.AcademicPress.

      Thereagentsinthiskitarenotapplicationspecificbutrathermaybeusedinavarietyofprocedures,dependingupontheneedsoftheindividualinvestigator.ThecombinationofCy5andFluoresceinlabelspermitssimultaneouslabelingofIntegrinalphaVbeta3andPECAMinflowcytometryorimmunofluorescence.

      Thiskitandreagentsisnotintendedforuseinadiagnosticorclinicalsetting.
      ProductInformation
      Components
      • IntegrinalphaVbeta3Cy5-conjugatedMouseMonoclonalAntibody(PartNo.MAB1976S-100)-1tube,100μg.
      • PECAM[CD31]Fluorescein-conjugatedMouseMonoclonalAntibody(PartNo.MAB2148F-100)-1tube,100μg.
      Presentation100μgeachofmonoclonalstoalphaVbeta3andPECAM,labeledwithCY5andFITC,respectively.
      StorageandShippingInformation
      StorageConditionsStoreantibodiesat2-8°C.Protectfromlight.

      ImportantNote:Duetothesmallvolumescontainedwithinthekit,werecommendgentlytappingthevialonahardsurfaceorbrieflycentrifugingthevialinatabletopcentrifugetodislodgeanyliquidentrappedinthecontainer"scapduringshipment.
      Applications
      KeyApplications
      • ELISA
      • Immunocytochemistry
      • Immunohistochemistry
      • Immunoprecipitation
      • FlowCytometry
      • AffectsFunction
      BIOLOGicalInformation
      SpeciesReactivity
      • Human
      EntrezGeneNumber
      EntrezGeneSummaryITAGVencodesintegrinalphachainV.Integrinsareheterodimericintegralmembraneproteinscomposedofanalphachainandabetachain.TheI-domaincontainingintegrinalphaVundergoespost-translationalcleavagetoyielddisulfide-linkedheavyandlightchains,thatcombinewithmultipleintegrinbetachainstoformdifferentintegrins.Amongtheknownassociatingbetachains(betachains1,3,5,6,and8;"ITGB1","ITGB3","ITGB5","ITGB6",and"ITGB8"),eachcaninteractwithextracellularmatrixligands;thealphaVbeta3integrin,perhapsthemoststudiedofthese,isreferredtoastheVitronectinreceptor(VNR).Inadditiontoadhesion,manyintegrinsareknowntofacilitatesignaltransduction.
      GeneSymbol
      • ITGAV
      • CD51
      • DKFZp686A08142
      • VNRA
      • MSK8
      UniProtNumber
      UniProtSummaryFUNCTION:SwissProt:P06756#Thealpha-Vintegrinsarereceptorsforvitronectin,cytotactin,fibronectin,fibrinogen,laminin,matrixmetalloproteinase-2,osteopontin,osteomodulin,prothrombin,thrombospondinandvonWillebrandfactor.TheyrecognizethesequenceR-G-Dinawidearrayofligands.IncaseofHIV-1infection,theinteractionwithextracellularviralTatproteinseemstoenhanceangiogenesisinKaposi"ssarcomalesions.
      SIZE:1048aminoacids;116038Da
      SUBUNIT:Heterodimerofanalphaandabetasubunit.Thealphasubunitiscomposedofanheavyandalightchainlinkedbyadisulfidebond.Alpha-Vassociateswitheitherbeta-1,beta-3,beta-5,beta-6orbeta-8subunit.InteractswithHIV-1Tat.
      SUBCELLULARLOCATION:Membrane;Single-passtypeImembraneprotein.
      SIMILARITY:SwissProt:P06756##Belongstotheintegrinalphachainfamily.&Contains7FG-GAPrepeats.
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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