BackgroundInformation | TheCD54antigenisasinglechainglycoproteinwithamolecularmassof90kDa(Springer,1990).Itisthehumanintercellularadhesionmolecule-1(ICAM-1)belongingtotheimmunoglobulinsupergenefamily.TheligandforICAM-1isLFA-1(leucocytefunctionassociated-1protein)(Berendt,1992).ICAM-1iswidelyexpressedonmanycelltypes,althoughthedegreeofexpressionbyunstimulatedrestingcellsvaries.AsacellularactivationantigentheexpressionofICAM-1isup-regulateduponcellactivation,beinginducedparticularlyinresponsetocytokinessuchasinterleukin-1,tumornecrosisfactor,andinterferon-?(Berendt,1992;Wellicome,1990;Thornhill,1990).ICAM-1mightbeareceptorforrhinovirus(Staunton,1989).Inrejectingkidneystheantibodystainsallinfiltratingcellsstronglyaswellasglomerulusepithelium,endotheliumoncapillaries,largevessels,andmesangium(Waugh,1989). |