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Abnova/CCND1 Split FISH Probe/1kit/FS0066
  • Abnova/CCND1 Split FISH Probe/1kit/FS0066

Abnova/CCND1 Split FISH Probe/1kit/FS0066

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貨號: FS0066
品牌: Abnova
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      • Specification
      • Gene Info
      • Pathway
      • Disease
      • Related Products
      • List All
      • Specification
      • Product Description:
      • Labeled FISH probes for identification of gene split using Fluoresecent In Situ Hybridization Technique. (Technology)
      • Form:
      • Liquid
      • Quality Control Testing:
      • Representative images of normal human cell (lymphocyte) stain with the dual color FISH probe. The left image is chromosomes at metaphase, and the right image is an interphase nucleus.QC Testing of FS0066
      • Supplied Product:
      • DAPI Counterstain (1500 ng/mL ) 125 uL for each 100 uL FISH Probe
      • Storage Instruction:
      • Store at 4°C in the dark.
      • Probe 1:Size:Fluorophore:Location:
      • CCND1Approximately 610kbTexas Red11q13
      • Probe 2:Size:Fluorophore:Location:
      • CCND1Approximately 660kbFITC11q13
      • Origin:
      • Human
      • Source:
      • Genomic DNA
      • Notice:
      • We strongly recommend the customer to use FFPE FISH PreTreatment Kit 1 (Catalog #: KA2375 or KA2691) for the pretreatment of Formalin-Fixed Paraffin-Embedded (FFPE) tissue sections.
      • Regulation Status:
      • For research use only (RUO)
      • Probe Position:
      • Datasheet:
      • PDF DownloadDownload
      • Applications
      • Fluorescent In Situ Hybridization (Cell)
      • PDF DownloadProtocol Download
      • Application Image
      • Fluorescent In Situ Hybridization (Cell)
      • Gene Information
      • Entrez GeneID:
      • 595
      • Gene Name:
      • CCND1
      • Gene Alias:
      • BCL1,D11S287E,PRAD1,U21B31
      • Gene Description:
      • cyclin D1
      • Omim ID:
      • 151400, 168461, 193300, 254500
      • Gene Ontology:
      • Hyperlink
      • Gene Summary:
      • The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. [provided by RefSeq
      • Other Designations:
      • B-cell CLL/lymphoma 1,G1/S-specific cyclin D1
      • Gene Pathway
      • Acute myeloid leukemia
      • Bladder cancer
      • Cell cycle
      • Chronic myeloid leukemia
      • Colorectal cancer
      • Endometrial cancer
      • Focal adhesion
      • Glioma
      • Jak-STAT signaling pathway
      • Melanoma
      • Non-small cell lung cancer
      • p53 signaling pathway
      • Pancreatic cancer
      • Pathways in cancer
      • Prostate cancer
      • Small cell lung cancer
      • Thyroid cancer
      • Wnt signaling pathway
      • Related Disease
      • Adenocarcinoma
      • Adenocarcinoma, Mucinous
      • Adenoma
      • Ataxia telangiectasia
      • Barrett Esophagus
      • Brain Neoplasms
      • Breast cancer
      • Breast Neoplasms
      • Breast Neoplasms, Male
      • Carcinoma
      • Carcinoma in Situ
      • Carcinoma, Basal Cell
      • Carcinoma, Hepatocellular
      • Carcinoma, Non-Small-Cell Lung
      • Carcinoma, Renal Cell
      • Carcinoma, Squamous Cell
      • Carcinoma, Transitional Cell
      • Cell Transformation, Neoplastic
      • Cell Transformation, Viral
          • ... see more
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