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Abnova/bcr/abl DY Translocation FISH Probe/1kit/FT0002
  • Abnova/bcr/abl DY Translocation FISH Probe/1kit/FT0002

Abnova/bcr/abl DY Translocation FISH Probe/1kit/FT0002

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貨號(hào): FT0002
品牌: Abnova
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  • 詳情
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  • 常見問題
      • Specification
      • Gene Info
      • Interactome
      • Related Products
      • List All
      • Specification
      • Product Description:
      • Labeled FISH probes for identification of gene translocation using Fluorescent In Situ Hybridization Technique. (Technology)
      • Form:
      • Liquid
      • Quality Control Testing:
      • Representative images of normal human cell (lymphocyte) stain with the dual color FISH probe. The left image is chromosomes at metaphase, and the right image is an interphase nucleus.QC Testing of FT0002
      • Supplied Product:
      • DAPI Counterstain (1500 ng/mL ) 125 uL for each 100 uL FISH Probe
      • Storage Instruction:
      • Store at 4°C in the dark.
      • Note:
      • Hybridization position of the probes on the chromosome.
      • Probe 1:Size:Fluorophore:Location:
      • BCRApproximately 1520kbFITC22q11.23
      • Probe 2:Size:Fluorophore:Location:
      • ABL Approximately 780kbTexas Red9q34.1
      • Notice:
      • We strongly recommend the customer to use FFPE FISH PreTreatment Kit 1 (Catalog #: KA2375 or KA2691) for the pretreatment of Formalin-Fixed Paraffin-Embedded (FFPE) tissue sections.
      • Regulation Status:
      • For research use only (RUO)
      • Datasheet:
      • PDF DownloadDownload
      • Applications
      • Fluorescent In Situ Hybridization (Cell)
      • PDF DownloadProtocol Download
      • Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
      • Fluorescent <i>In Situ<i/> Hybridization (Formalin/PFA-fixed paraffin-embedded sections)enlargeenlarge this image
      • Human lymph node (FFPE) stained with bcr/abl DY Translocation FISH Probe. Human lymph node cancer showed no bcr/abl DY Translocation.
      • PDF DownloadProtocol Download
      • Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
      • Fluorescent <i>In Situ<i/> Hybridization (Formalin/PFA-fixed paraffin-embedded sections)enlargeenlarge this image
      • Human CML (FFPE) stained with bcr/abl DY Translocation FISH Probe. Human CML showed bcr/abl gene translocation.
      • PDF DownloadProtocol Download
      • Application Image
      • Fluorescent In Situ Hybridization (Cell)
      • Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
      • Fluorescent <i>In Situ<i/> Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
      • enlarge
      • Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
      • Fluorescent <i>In Situ<i/> Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
      • enlarge
      • ABL1
      • BCR
      • Gene Information
      • Entrez GeneID:
      • 613
      • Gene Name:
      • BCR
      • Gene Alias:
      • ALL,BCR-ABL1,BCR1,CML,D22S11,D22S662,FLJ16453,PHL
      • Gene Description:
      • breakpoint cluster region
      • Omim ID:
      • 151410, 608232
      • Gene Ontology:
      • Hyperlink
      • Gene Summary:
      • A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
      • Other Designations:
      • bcr-abl1 e14a3 chimeric protein
      • Gene Information
      • Entrez GeneID:
      • 25
      • Gene Name:
      • ABL1
      • Gene Alias:
      • ABL,JTK7,bcr/abl,c-ABL,p150,v-abl
      • Gene Description:
      • c-abl oncogene 1, receptor tyrosine kinase
      • Omim ID:
      • 189980
      • Gene Ontology:
      • Hyperlink
      • Gene Summary:
      • The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response.Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene.The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia.The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1.The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11. [provided by RefSeq
      • Other Designations:
      • Abelson murine leukemia viral (v-abl) oncogene homolog 1,OTTHUMP00000022375,OTTHUMP00000022376,bcr/c-abl oncogene protein,proto-oncogene tyrosine-protein kinase ABL1,v-abl Abelson murine leukemia viral oncogene homolog 1
      • Interactome
      • Interactome
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