The protein encoded by this gene is a member of the CXC chemokine family. This chemokine is one of the major mediators of the inflammatory response. This chemokine is secreted by several cell types. It functions as a chemoattractant, and is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other ten members of the CXC chemokine gene family form a chemokine gene cluster in a region mapped to chromosome 4q. [provided by RefSeq
Other Designations:
T cell chemotactic factor,beta-thromboglobulin-like protein,chemokine (C-X-C motif) ligand 8,emoctakin,granulocyte chemotactic protein 1,lymphocyte-derived neutrophil-activating factor,monocyte-derived neutrophil chemotactic factor,neutrophil-activating p
Gene Pathway
Bladder cancer
Chemokine signaling pathway
Cytokine-cytokine receptor interaction
Epithelial cell signaling in Helicobacter pylori infection
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4000-520-616
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