Immunogen | PurifiedbovineS-100protein |
Epitope | Recognizesbothalpha&betaS100 |
Clone | 15E2E2 |
Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
Host | Mouse |
Specificity | Recognizesintact,alphaandbetasubunitsofbovine,human,andmurineS-100protein,asdeterminedbyimmunoprecipitationprofiles. |
Isotype | IgG2aκ |
SpeciesReactivity | |
AntibodyType | MonoclonalAntibody |
EntrezGeneNumber | |
EntrezGeneSummary | TheproteinencodedbythisgeneisamemberoftheS100familyofproteinscontaining2EF-handcalcium-bindingmotifs.S100proteinsarelocalizedinthecytoplasmand/ornucleusofawiderangeofcells,andinvolvedintheregulationofanumberofcellularprocessessuchascellcycleprogressionanddifferentiation.S100genesincludeatleast13memberswhicharelocatedasaclusteronchromosome1q21.ThisproteinmayfunctioninstimulationofCa2+-inducedCa2+release,inhibitionofmicrotubuleassembly,andinhibitionofproteinkinaseC-mediatedphosphorylation.Reducedexpressionofthisproteinhasbeenimplicatedincardiomyopathies. |
GeneSymbol | - S100A1
- S100A
- S100
- S100-alpha
|
PurificationMethod | ProteinAPurfied |
UniProtNumber | |
UniProtSummary | FUNCTION:SwissProt:P23297#Weaklybindscalciumbutbindszincverytightly-distinctbindingsiteswithdifferentaffinitiesexistforbothionsoneachmonomer.Physiologicalconcentrationsofpotassiumionantagonizethebindingofbothdivalentcations,especiallyaffectinghigh-affinitycalcium-bindingsites. SIZE:94aminoacids;10546Da SUBUNIT:Dimerofeithertwoalphachains,ortwobetachains,oronealphaandonebetachain. SUBCELLULARLOCATION:Cytoplasm. TISSUESPECIFICITY:Highlyprevalentinheart.Alsofoundinlesserquantitiesinskeletalmuscleandbrain. SIMILARITY:SwissProt:P23297##BelongstotheS-100family.&Contains2EF-handdomains. |