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Millipore/MAB16985B | Anti-MCAM Antibody, clone P1H12, biotin conjugated/MAB16985B/100 µg
  • Millipore/MAB16985B | Anti-MCAM Antibody, clone P1H12, biotin conjugated/MAB16985B/100 µg

Millipore/MAB16985B | Anti-MCAM Antibody, clone P1H12, biotin conjugated/MAB16985B/100 µg

價格: ￥4068.00 市場價: 6780.00
貨號: MAB16985B
品牌: Millipore
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    • Description
      CatalogueNumberMAB16985B
      BrandFamilyChemicon®
      TradeName
      • Chemicon
      DescriptionAnti-MCAMAntibody,cloneP1H12,biotinconjugated
      AlternateNames
      • MUC18
      • CD146
      BackgroundInformationMUC18antigen(CD146),amemberoftheimmuoglobulinsuperfamily,isanintrinsicmembraneglycoproteinof110-120kDafoundonthesurfaceofendothelialcells,bonemarrowfibroblastsandvariousmelanomas.MUC18hasbeenusedasaMarkeroftumorprogressioninhumanmelanomabecauseexpressioninthosetumorscorrelatesstronglywithpoorprognosisandthedevelopmentofmetasticdisease.Inaddition,anumberofhumanT,BandmyeloidleukemiccelllinesseemtoexpressMUC18.TheclosestructuralrelationshipwithN-CAMandrelatedmoleculessuggeststhatMUC18maybealsoadevelopmentallyregulatedcelladhesionmolecule(MelanomaadhesionmoleculeorMCAM).
      ProductInformation
      FormatBiotin
      PresentationPurifiedimmunoglobulin.Liquidin0.02MPBS,0.25MNaCl,pH=7.6,15mg/nLBSAcontaining0.1%sodiumazideasapreservative.
      StorageandShippingInformation
      StorageConditionsStoreat2-8°Cforupto12months.

      Duringshipment,smallvolumesofproductwilloccasionallybecomeentrappedinthesealoftheproductvial.Forproductswithvolumesof200μLorless,werecommendgentlytappingthevialonahardsurfaceorbrieflycentrifugingthevialinatabletopcentrifugetodislodgeanyliquidinthecontainer"scap.
      Applications
      ApplicationThisAnti-MCAMAntibody,cloneP1H12,biotinconjugatedisvalidatedforuseinELISA,FC,IP,IC,IHforthedetectionofMCAM.
      KeyApplications
      • ELISA
      • FlowCytometry
      • Immunoprecipitation
      • Immunocytochemistry
      • Immunohistochemistry
      ApplicationNotesImmunocytochemistry:1-10μg/mL.WorksbestonEDTAorTrypsinliftedendothelialcells.

      Immunohistochemistry:1-10μg/mL.4%PFAfor30minRTor<2hrs @4°c.="" block="" w/="" 1%bsa/0.2%tween20/pbc="" for="" 30min.="" works="" well="" in="" frozen="" tissue;="" fixed="" or="" unfixed.="">

      Immunoprecipitation:1-10μg/mL

      ELISA:1-10μg/mL

      FacsAnalysis:1-10μg/mL

      Optimalworkingdilutionsandprotocolsmustbedeterminedbyenduser.
      BIOLOGicalInformation
      ImmunogenImmunizationofmicewithHUVEC
      CloneP1H12
      ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
      HostMouse
      SpecificityP1H12reactsspecificallywithCD146{MCAM,MUC18}.InbloodandmarrowP1H12reactsonlywithendothelialcells,andhasbeenusedtodetectcirculatingendothelialcellsinhuman,dogsandmousesamples.Itpositivelystainsnormal,primaryHUVECandMVECculturesandtheendothelialcellsofallvesselsinnormalfrozensectionsofhumanskin,intestine,ovarytonsil,lymphnode,lung,andkidney.ItdoesnotstaincarcinomacelllinesHT-29andCOLO205,andM21,theTcelllinesJurkatandHuT78,fibroblasts,HL-60orCHOcells,orEBV-transformedBcelllines,althoughitexpectedthatCD146expressionispresentinmanytumorlines.P1H12doesnotstainnormalmonocytes,granulocytes,redcells,platelets,TcellsorBcellsfrommarroworperipheralblood;nordoesitdetectmarrowmegakaryocytesorthemegakaryoblastlineHU3.TheperipheralbloodcellsthatdostainwithP1H12alsoarepositiveforbothvonWillebrandFactor(vWF)andthrombomodulin(thecombinedexpressionofwhichislimitedtoendothelium),andtheystainforfltandflk.Inrecenttesting,melanomaA2058,SKMEL.3andA375.S2arepositive,whilemurinemelanomaM3isnegative.Onesmoothmuscleline(HISM)waspositiveandonenegative(TIGHA-VSMC).Humanbloodlymphoctesarenegativewithorwithoutpriorstimulation.
      IsotypeIgG1
      SpeciesReactivity
      • Canine
      • Human
      • Mouse
      SpeciesReactivityNoteDetectscirculatingendothelialcellsinhuman.Expectedtocross-reactwithdog&mouse.
      AntibodyTypeMonoclonalAntibody
      EntrezGeneNumber
      GeneSymbol
      • MCAM
      • Gicerin
      • MUC18
      • CD146
      Non-ReactiveSpecies
      • Rat
      UniProtNumber
      UniProtSummaryFUNCTION:SwissProt:P43121#Playsaroleincelladhesion,andincohesionoftheendothelialmonolayeratintercellularjunctionsinvasculartissue.Itsexpressionmayallowmelanomacellstointeractwithcellularelementsofthevascularsystem,therebyenhancinghematogeneoustumorspread.Couldbeanadhesionmoleculeactiveinneuralcrestcellsduringembryonicdevelopment.ActsassurfacereceptorthattriggerstyrosinephosphorylationofFYNandPTK2,andatransientincreaseintheintracellularcalciumconcentration.
      SIZE:646aminoacids;71607Da
      SUBCELLULARLOCATION:Membrane;Single-passtypeImembraneprotein.
      TISSUESPECIFICITY:Detectedinendothelialcellsinvasculartissuethroughoutthebody.Mayappearatthesurfaceofneuralcrestcellsduringtheirembryonicmigration.Appearstobelimitedtovascularsmoothmuscleinnormaladulttissues.Associatedwithtumorprogressionandthedevelopmentofmetastasisinhumanmalignantmelanoma.ExpressedmoststronglyonmetastaticlesionsandadvancedprimarytumorsandisonlyrarelydetectedinbenignmelanocyticneviandthinprimarymelanomaswithalowprobABIlityofmetastasis.
      SIMILARITY:SwissProt:P43121##Contains3Ig-likeC2-type(immunoglobulin-like)domains.&Contains2Ig-likeV-type(immunoglobulin-like)domains.
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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