Immunogen | AcetylcholinesteraseAChEfromhumanerythrocyte. |
Clone | AE-1 |
Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
Host | Mouse |
Specificity | Acetylcholinesterasefromhumanandmonkey. |
Isotype | IgG1 |
SpeciesReactivity | - Bovine
- Canine
- Chicken
- GuineaPig
- Human
- Monkey
|
AntibodyType | MonoclonalAntibody |
EntrezGeneNumber | |
EntrezGeneSummary | Acetylcholinesterasehydrolyzestheneurotransmitter,acetylcholineatneuromuscularjunctionsandbraincholinergicsynapses,andthusterminatessignaltransmission.Itisalsofoundontheredbloodcellmembranes,whereitconstitutestheYtbloodgroupantigen.Acetylcholinesteraseexistsinmultiplemolecularformswhichpossesssimilarcatalyticproperties,butdifferintheiroligomericassemblyandmodeofcellattachmenttothecellsurface.ItisencodedbythesingleACHEgene,andthestructuraldiversityinthegeneproductsarisesfromalternativemRNAsplicing,andpost-translationalassociationsofcatalyticandstructuralsubunits.Themajorformofacetylcholinesterasefoundinbrain,muscleandothertissuesisthehydrophilicspecies,whichformsdisulfide-linkedoligomerswithcollagenous,orlipid-containingstructuralsubunits.Theother,alternativelysplicedform,expressedprimarilyintheerythroidtissues,differsattheC-terminalend,andcontainsacleavablehydrophobicpeptidewithaGPI-anchorsite.Itassociateswiththemembranesthroughthephosphoinositide(PI)moietiesaddedpost-translationally. |
GeneSymbol | - ACHE
- N-ACHE
- acetylcholinesterase
- AChE
- YT
- ARACHE
- EC3.1.1.7
|
UniProtNumber | |
UniProtSummary | FUNCTION:SwissProt:P22303#Rapidlyhydrolyzescholinereleasedintothesynapse. SIZE:614aminoacids;67796Da SUBUNIT:Homotetramer;composedofdisulfide-linkedhomodimers.InteractswithPRIMA1.TheinteractionwithPRIMA1isrequiredtoanchorittothebasallaminaofcellsandorganizeintotetramers(Bysimilarity). SUBCELLULARLOCATION:Celljunction,synapse.Secreted(Bysimilarity).Cellmembrane;Peripheralmembraneprotein(Bysimilarity).&Isoform2:Cellmembrane;Lipid-anchor,GPI-anchor;Extracellularside(Bysimilarity). SIMILARITY:SwissProt:P22303##Belongstothetype-Bcarboxylesterase/lipasefamily. |