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Millipore/MAB3199Z | Anti-E-Cadherin Antibody, clone 67A4, Azide Free/MAB3199Z/100 µg
  • Millipore/MAB3199Z | Anti-E-Cadherin Antibody, clone 67A4, Azide Free/MAB3199Z/100 µg

Millipore/MAB3199Z | Anti-E-Cadherin Antibody, clone 67A4, Azide Free/MAB3199Z/100 µg

價格: ￥4068.00 市場價: 6780.00
貨號: MAB3199Z
品牌: Millipore
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    • Description
      CatalogueNumberMAB3199Z
      BrandFamilyChemicon®
      TradeName
      • Chemicon
      DescriptionAnti-E-CadherinAntibody,clone67A4,AzideFree
      AlternateNames
      • CD324
      • MAB3199
      ProductInformation
      FormatPurified
      PresentationLiquidin0.02MPBSwithNaCl,pH=7.6,withnopreservatives.ProteinApurifiedimmunoglobulin.
      StorageandShippingInformation
      StorageConditionsMaintainat-20°Cinundilutedaliquotsforupto12months.
      Applications
      ApplicationAnti-E-CadherinAntibody,clone67A4,AzideFreeisanantibodyagainstE-CadherinforuseinFC&IF.
      KeyApplications
      • FlowCytometry
      • Immunofluorescence
      • AffectsFunction
      ApplicationNotesImmunoblotting

      FACSAnalysis

      FunctionalblockingofE-cadherin

      Doesnotworkwellforimmunoprecipitation

      Optimalworkingdilutionsmustbedeterminedbyenduser.
      BIOLOGicalInformation
      ImmunogenT-47Dbreastcarcinomaline.
      Clone67A4
      ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
      HostMouse
      SpecificityAntibodiesagainstE-cadherinaresuitabletocharacterizeepithelialcells.E-Cadherinisinvolvedinadhesionofepithelialcells(mostlyhomotypicandhomophilic).E-cadherinisalsoexpressedonimmatureerythroidcells.Theantibody67A4issuitabletostudyEcadherinexpressionbyflowcytometry.Inaddition,itblockstheinteractionofE-cadherinmoleculesandthereforeissuitabletostudyE-cadherin-mediatedsignaltransduction.
      IsotypeIgG1
      SpeciesReactivity
      • Human
      AntibodyTypeMonoclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryThisgeneisaclassicalcadherinfromthecadherinsuperfamily.Theencodedproteinisacalciumdependentcell-celladhesionglycoproteincomprisedoffiveextracellularcadherinrepeats,atransmembraneregionandahighlyconservedcytoplasmictail.Mutationsinthisgenearecorrelatedwithgastric,breast,colorectal,thyroidandovariancancer.Lossoffunctionisthoughttocontributetoprogressionincancerbyincreasingproliferation,invasion,and/ormetastasis.Theectodomainofthisproteinmediatesbacterialadhesiontomammaliancellsandthecytoplasmicdomainisrequiredforinternalization.Identifiedtranscriptvariantsarisefrommutationatconsensussplicesites.
      GeneSymbol
      • CDH1
      • CDHE
      • E-cadherin
      • Arc-1
      • Uvomorulin
      • UVO
      • Cadherin-1
      • CD324
      • uvomorulin
      • ECAD
      • LCAM
      UniProtNumber
      UniProtSummaryFUNCTION:SwissProt:P12830#E-Cad/CTF2promotesnon-amyloidogenicdegradationofAbetaprecursors.HasastronginhibitoryeffectonAPPC99andC83production.
      SIZE:882aminoacids;97456Da
      SUBUNIT:Homodimer;disulfide-linked.Interactsdirectly,viathecytoplasmicdomain,withCTNNB1orJUPtoformthePSEN1/cadherin/cateninadhesioncomplexwhichconnectstotheactinskeletonthroughtheactinbindingofalpha-catenin.InteractionwithPSEN1,cleavesCDH1resultinginthedisassociationofcadherin-basedadherensjunctions(CAJs).InteractswithAJAP1,CTNND1andDLG7.
      SUBCELLULARLOCATION:Celljunction.Cellmembrane;Single-passtypeImembraneprotein.Note=ColocalizeswithDLG7atsitesofcell-cellcontactinintestinalepithelialcells.AnchoredtoactinMICROFILamentsthroughassociationwithalpha-,beta-andgamma-catenin.Sequentialproteolysisinducedbyapoptosisorcalciuminflux,resultsintranslocationfromsitesofcell-cellcontacttothecytoplasm.
      TISSUESPECIFICITY:Non-neuralepithelialtissues.
      PTM:Duringapoptosisorwithcalciuminflux,cleavedbyamembrane-boundmetalloproteinase(ADAM10),PS1/gamma-secretaseandcaspase-3toproducefragmentsofabout38kDa(E-CAD/CTF1),33kDa(E-CAD/CTF2)and29kDa(E-CAD/CTF3),respectively.Processingbythemetalloproteinase,inducedbycalciuminflux,causesdisruptionofcell-celladhesionandthesubsequentreleaseofbeta-cateninintothecytoplasm.Theresidualmembrane-tetheredcleavageproductisrapidlydegradedviaanintracellularproteolyticpathway.Cleavagebycaspase-3releasesthecytoplasmictailresultingindisintegrationoftheactinmicrofilamentsystem.Thegamma-secretase-mediatedcleavagepromotesdisaaaemblyofadherensjunctions.
      DISEASE:"SwissProt:P12830#DefectsinCDH1areinvolvedindysfunctionofthecell-celladhesionsystem,triggeringcancerinvasion(gastric,breast,ovary,endometriumandthyroid)andmetastasis.&DefectsinCDH1areacauseofhereditarydiffusegastriccancer(HDGC)[MIM:137215].&DefectsinCDH1areacauseofsusceptibilitytoendometrialcancer[MIM:608089]."
      SIMILARITY:SwissProt:P12830##Contains5cadherindomains.
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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