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Millipore/MAB5520 | Anti-NG2 Chondroitin Sulfate Proteoglycan Antibody, clone 7.1/MAB5520/100 µL
  • Millipore/MAB5520 | Anti-NG2 Chondroitin Sulfate Proteoglycan Antibody, clone 7.1/MAB5520/100 µL

Millipore/MAB5520 | Anti-NG2 Chondroitin Sulfate Proteoglycan Antibody, clone 7.1/MAB5520/100 µL

價格: ￥3816.00 市場價: 6360.00
貨號: MAB5520
品牌: Millipore
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    • Description
      CatalogueNumberMAB5520
      BrandFamilyChemicon®
      TradeName
      • Chemicon
      DescriptionAnti-NG2ChondroitinSulfateProteoglycanAntibody,clone7.1
      AlternateNames
      • NG2
      ProductInformation
      FormatAscites
      PresentationAscitesfluid.Liquid.Containsnopreservative.
      StorageandShippingInformation
      StorageConditionsMaintainat-20°Cinundilutedaliquotsforupto12monthsafterdateofreceipt.Avoidrepeatedfreeze/thawcycles.
      Applications
      ApplicationAnti-NG2ChondroitinSulfateProteoglycanAntibody,clone7.1isanantibodyagainstNG2ChondroitinSulfateProteoglycanforuseinFC&WB.
      KeyApplications
      • FlowCytometry
      • WesternBlotting
      ApplicationNotesWesternblot

      Flowcytometry

      Optimalworkingdilutionsmustbedeterminedbyenduser.
      BIOLOGicalInformation
      ImmunogenHumanbonemarrowstromalcellline,SV40transformed.
      Clone7.1
      HostMouse
      SpecificityNG2(chondroitinsulfateproteoglycan),humanwhichisthehomologueoftheratNG2molecule.Theantibodyreactswitha220-240kDsurfaceproteinwhoseN-terminalsequenceisidenticaltotheratNG2chondrotinsulfateproteoglycanmolecule.

      MAB5520reactswithonlyneoplasticleukocyteswithspecificassociationwithchromosome11q23translocationsinvolvingtheMLLgene.Ithasaveryhighspecificityfort(4;11)ort(11;19)translocations.Theantibodyshowsnoreactivitywithnormalmarrowhematopoieticcells,peripheralblldleukocytes,redbloodcellsorplatelets.LeukemiccellslinesKG1,KG1a,HRL,Jurkat,K562,Raji,HL-60,U937,Daudi,Nalm6andCEMarenegative.HoweverMAB5520doesreactwithavarietyofcelllinesofnonhematopoieticorigin,includingHeLacells.
      IsotypeIgG1
      SpeciesReactivity
      • Human
      AntibodyTypeMonoclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryAhumanmelanoma-associatedchondroitinsulfateproteoglycanplaysaroleinstABIlizingcell-substratuminteractionsduringearlyeventsofmelanomacellspreADIngonendothelialbasementmembranes.CSPG4representsanintegralmembranechondroitinsulfateproteoglycanexpressedbyhumanmalignantmelanomacells.
      GeneSymbol
      • CSPG4
      • MSK16
      • MCSP
      • NG2
      • MCSPG
      • MEL-CSPG
      • HMW-MAA
      UniProtNumber
      UniProtSummaryFUNCTION:SwissProt:Q6UVK1#Proteoglycanplayingaroleincellproliferationandmigrationwhichstimulatesendothelialcellsmotilityduringmicrovascularmorphogenesis.Mayalsoinhibitneuriteoutgrowthandgrowthconecollapseduringaxonregeneration.Cellsurfacereceptorforcollagenalpha2(VI)whichmayconfercellsabilitytomigrateonthatsubstrate.BindsthroughitsextracellularN-terminusgrowthfactors,extracellularmatrixproteasesmodulatingtheiractivity.MayregulateMPP16-dependentdegradationandinvasionoftypeIcollagenparticipatinginmelanomacellsinvasionproperties.Maymodulatetheplasminogensystembyenhancingplasminogenactivationandinhibitingangiostatin.FunctionsalsoasasignaltransducingproteinbybindingthroughitscytoplasmicC-terminusscaffoldingandsignalingproteins.MaypromoteretractionfiberformationandcellpolarizationthroughRhoGTPaseactivation.Maystimulatealpha-4,beta-1integrin-mediatedadhesionandspreadingbyrecruitingandactivatingasignalingcascadethroughCDC42,ACK1andBCAR1.MayactivateFAKandERK1/ERK2signalingcascades.


      SIZE:2322aminoacids;250497Da

      SUBUNIT:InteractswiththefirstPDZdomainofMPDZ.InteractswithPRKCA.BindsTNC,laminin-1,COL5A1andCOL6A2.InteractswithPLGandangiostatin.BindsFGF2andPDGFA.InteractswithGRIP1,GRIP2andGRIA2.FormsaternarycomplexwithGRIP1andGRIA2(Bysimilarity).InteractswithLGALS3andtheintegrincomposedofITGB1andITGA3.InteractswithITGA4throughitschondroitinsulfateglycosaminoglycan.InteractswithBCAR1,CDC42andACK1.InteractswithMMP16.

      SUBCELLULARLOCATION:Apicalcellmembrane;Single-passtypeImembraneprotein(Bysimilarity).Cellprojection,lamellipodium(Bysimilarity).Note=LocalizedattheapicalplasmamembraneitrelocalizestothelamellipodiaofastrocytomauponphosphorylationbyPRKCA.Localizestotheretractionfibers.Localizestotheplasmamembraneofoligodendrocytes(Bysimilarity).

      TISSUESPECIFICITY:Detectedonlyinmalignantmelanomacells.



      PTM:N-glycosylated(Bysimilarity).&O-glycosylated;containsglycosaminoglycanchondroitinsulfatewhicharerequiredforproperlocalizationandfunctioninstressfiberformation(Bysimilarity).InvolvedininteractionwithMMP16andITGA4.&PhosphorylationbyPRKCAregulatesitssubcellularlocationandfunctionincellmotility(Bysimilarity).


      SIMILARITY:SwissProt:Q6UVK1##Contains15CSPG(NG2)repeats.&Contains2lamininG-likedomains.

      MISCELLANEOUS:ValuableMarkerforseveralincompletelydifferentiatedprecursorcells.
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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