BackgroundInformation | Asamemberofthemembrane-associatedguanylatekinase(MAGUK)family,PSD93(alsoknownasChapsyn-110)bindsdirectlytotheN-methyl-D-aspartate(NMDA)receptorandtheShakerK+channelsubunits.Itshares70-80%homologywithPSD-95(SAP90),andSAP97.LikePSD-95,PSD93playsakeyroleinpostsynaptictargeting.Asidefrombindingtoglutamatereceptors,theMAGUKfamilyofproteinsalsointeractswithcellsurfacestructures,likecelladhesionmolecules,ionchannels,cytoskeletalelements,andsignaltransductionmolecules.ImproperPSD93signalinghasbeenimplicatedincertaindiseasestates,suchasschizophrenia. |