FELINE VIRAL RHINOTRACHEITIS ANTIGEN

Feline Viral Rhinotracheitis (FVR) antigen has been manufactured for use in the detection of antibodies against FVR (feline herpes virus, FHV-1) for immunoassay development or other applications.

PRODUCT DETAILS – FELINE VIRAL RHINOTRACHEITIS ANTIGEN

• Feline Viral Rhinotracheitis antigen, strain C-27.
• Native antigen purified from FVR infected CRFK cells.
• The antigen is presented in 0.05M Glycine, pH 9.
• This material has been UV and detergent inactivated (<0.1% CHAPS, <0.01% SDS).
• For ELISA development or other applications.

BACKGROUND

Feline respiratory disease complex is a group of respiratory illnesses caused by a number of organisms that can cause infection alone or together. It includes those illnesses with signs including inflammation of the nasal and sinus linings, inflammation of the eye lining (conjunctivitis), excessive tear production, salivation, and mouth sores. The principal diseases are feline viral rhinotracheitis (also called feline herpesvirus type 1; FHV-1) and feline calicivirus, although other diseases may also be involved, including feline infectious peritonitis virus (Kuehn, 2020).

The majority of feline upper respiratory infections are caused by feline viral rhinotracheitis (FVR), although the incidence of feline calicivirus may be higher in some populations of cats. Natural transmission of these agents occurs via aerosol droplets and fomites. The onset of FVR is characterised by fever, frequent sneezing, inflamed eyes (conjunctivitis), inflammation of the lining of the nose (rhinitis), and often salivation. Severely affected cats may develop mouth inflammation with sores, and inflammation of the cornea. Symptoms may last for 5-10 days in milder cases and up to 6 weeks in severe cases. The occurrence of severe viral upper respiratory disease is rare in adult, properly vaccinated cats. The outlook is generally good except for young kittens and older cats (Povey, 1979; Maes et al., 1984; Kuehn, 2020). Antiviral drugs developed for the treatment of humans infected with herpesviruses have been used to treat cats infected with FVR, with varying degrees of success (Thomasy & Maggs, 2016). Several intranasal modified-live virus FVR-FCV vaccines are available.

REFERENCE

• Kuehn, NF. Feline Respiratory Disease Complex (Feline Viral Rhinotracheitis, Feline Calicivirus). MSD Veterinary Manual, 2020.
• Maes et al. (1984). Immunogenic proteins of feline rhinotracheitis virus. J. Virol. 51:259–262.
• Povey R.C. (1979). A review of feline viral rhinotracheitis (feline herpesvirus I infection) Comp. Immunol. Microbiol. Infect. Dis. 2:373–387.
• Thomasy SM, Maggs DJ. (2016). A review of antiviral drugs and other compounds with activity against feline herpesvirus type 1. Vet Ophthalmol. 19 Suppl 1(Suppl 1):119–130.