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Abnova/ATXN1 polyclonal antibody/1kit/PAB29341
  • Abnova/ATXN1 polyclonal antibody/1kit/PAB29341

Abnova/ATXN1 polyclonal antibody/1kit/PAB29341

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貨號: PAB29341
品牌: Abnova
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      • Specification
      • Gene Info
      • Disease
      • Related Products
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      • Specification
      • Product Description:
      • Rabbit polyclonal antibody raised against recombinant human ATXN1.
      • Immunogen:
      • Recombinant protein corresponding to amino acids of human ATXN1.
      • Sequence:
      • RAPGLITPGSPPPAQQNQYVHISSSPQNTGRTASPPAIPVHLHPHQTMIPHTLTLGPPSQVVMQYADSGSHFVPREATKKAESSRLQQAIQAKEVLNGEMEKSRRYGAPSSADLGLGKAGGKSVPHP
      • Host:
      • Rabbit
      • Reactivity:
      • Human
      • Form:
      • Liquid
      • Purification:
      • Antigen affinity purification
      • Isotype:
      • IgG
      • Recommend Usage:
      • Immunohistochemistry (1:200-1:500)Immunofluorescence (1-4 ug/mL)The optimal working dilution should be determined by the end user.
      • Storage Buffer:
      • In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide)
      • Storage Instruction:
      • Store at 4°C. For long term storage store at -20°C.Aliquot to avoid repeated freezing and thawing.
      • Note:
      • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
      • Datasheet:
      • PDF DownloadDownload
      • Applications
      • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
      • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
      • Immunohistochemical staining of human cerebral cortex with ATXN1 polyclonal antibody (Cat# PAB29341) shows strong nuclear and cytoplasmic positivity in neuronal cells.
      • Immunofluorescence
      • Immunofluorescence
      • Immunofluorescent staining of human cell line A-431 with ATXN1 polyclonal antibody (Cat# PAB29341) under 1-4 ug/mL working concentration shows positivity in vesicles & nucleus but excluded from the nucleoli.
      • Application Image
      • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
      • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
      • enlarge
      • Immunofluorescence
      • Immunofluorescence
      • enlarge
      • Gene Information
      • Entrez GeneID:
      • 6310
      • Protein Accession#:
      • P54253
      • Gene Name:
      • ATXN1
      • Gene Alias:
      • ATX1,D6S504E,SCA1
      • Gene Description:
      • ataxin 1
      • Omim ID:
      • 164400, 601556
      • Gene Ontology:
      • Hyperlink
      • Gene Summary:
      • The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the `pure" cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations. The function of the ataxins is not known. This locus has been mapped to chromosome 6, and it has been determined that the diseased allele contains 41-81 CAG repeats, compared to 6-39 in the normal allele. At least two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq
      • Other Designations:
      • OTTHUMP00000016065,OTTHUMP00000039306,olivopontocerebellar ataxia 1, autosomal dominant,spinocerebellar ataxia 1 (olivopontocerebellar ataxia 1, autosomal dominant, ataxin 1)
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      • Bipolar Disorder
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      • Chronic Disease
      • Cognition
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      • Epilepsy
      • Fragile X Syndrome
      • Fragile X syndrome
      • Friedreich Ataxia
      • Friedreich"s ataxia
      • Genetic Predisposition to Disease
      • Genomic Instability
      • Huntington Disease
      • Huntington disease
      • Machado-Joseph Disease
      • Muscular Atrophy, Spinal
      • Myoclonic Epilepsies, Progressive
          • ... see more
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